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Table 5 Difference in variation explained for each trait in each annotation classes tested when compared with the same number of randomly chosen SNP

From: Regulatory and coding genome regions are enriched for trait associated variants in dairy and beef cattle

Traits

Upstream

Downstream

Intron

CDS

Synonymous

Missense

UTR (5'&3')

Non-coding conserved

Micro RNA target sites

Fat

−0.2

0.0

−2.4

3.8*

5.0*

5.1*

1.8

−1.1

−0.9

Fat Percent

8.7*

4.6*

1.9

18.4*

21.0*

20.0*

5.0*

−3.1*

−3.2*

Milk

2.2

1.2

−1.3

6.4*

7.5*

7.7*

3.4*

−0.3

0.5

Protein

−1.0

−1.4

−3.5*

1.2

1.7

3.2*

2.2

−0.6

0.6

Protein Percent

2.2

1.6

0.2

9.4*

10.9*

9.3*

5.9*

0.2

1.9

Angularity

−1.9

0.3

−1.2

−0.9

−0.5

−0.4

−1.2

0.9

−1.2

BCS

−0.9

−1.3

−1.1

0.6

−0.8

1.4

−1.3

1.2

−0.7

Mammary System

−1.1

−2.4

−0.9

0.1

1.1

−0.1

−0.3

0.1

−1.6

Fertility

−0.8

−0.2

0.5

−0.4

−0.2

0.1

0.0

0.1

−0.3

Survival Direct

−0.8

−1.6

−2.2

−1.9

−0.8

0.1

−1.0

−1.6

−0.7

SCC

−3.0

−3.3*

−2.2

0.5

0.3

0.1

−0.5

−0.1

−0.8

  1. This analysis was replicated 5 times, with significance determined as greater or less than the average of the proportion of variance explained by the same number of randomly selected intergenic SNP across five replicates +/− 2 times the standard error. Values with the symbol “*” indicate that there is a significant increase in variation explained (the differences is greater than 2 times the standard error from the random SNP sets) or a significant decrease in the variance explained (difference is greater than −2 times the standard error from the random SNP sets).