Figure 6

Correlation between lncRNAs and remodeling genes. Microarray data from the derivation group of 4 sham-operated and 4 MI mice were used in these analyses. A. Networks indicating the strength of the correlation between the lncRNAs MIRT1 and MIRT2 and 38 coding genes known to be involved in remodeling (“remodeling genes”). Remodeling genes differentially expressed between sham-operated and MI mice are coloured, with darker colour indicating a strong differential expression. Red colour indicates a higher level of expression in MI mice compared to sham-operated mice. Remodeling genes unaffected by MI are in white circles. A q-value <5% was used as threshold for differential expression between sham and MI mice (significance analysis of microarrays method). The thickness of the edges indicates the strength of the correlation between the lncRNAs and remodeling genes. Dotted lines indicate no correlation. A p-value <0.05 was used as significance threshold for correlation (Spearman’s rank correlation and Student’s test). B. List of the remodeling genes significantly (p < 0.05) correlated with lncRNAs and differentially expressed between sham-operated and MI mice. r indicates correlation coefficient and p indicates p-value. C. Kinetic of the expression of remodeling genes after MI. The 21 mice sacrificed at different time-points after MI were used in these analyses (n = 3 per time-point). P values obtained by ANOVA are indicated.