Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates

BMC Genomics

Table 3 SNPs and identified in antibiotic resistance-associated regions in M. tuberculosis isolate s

			Mutations in target gene or intergenic regions (corresponding drugs)^a
Isolates	Rv3919c ( gidB) (STR)	Rv3793 ( embC) (EMB)	Rv3794 ( embA) (EMB)	Rv3795 ( embB) (EMB)	Rv2043c ( pncA) (PZA)	Rv0006 ( gyrA) (OFX, LVX)	Rvnr01 ( rrs) (KAN, CAP, AMK)	Rv1694 ( tlyA) (KAN, CAP, AMK)	Rv3854c ( ethA) (ETH)
Mtb562	S100F^g	R927^e	None	None	None	S95T^g	None	None	Q360H^g
Mtb526	E92D^g,S100F^g,A205^e	V885M^f,g,R927^e	C76^e	None	None	E21Q^g,S95T^g,G668D^f,g	None	L11^e	Q360H^g
Mtb194	E92D^g,S100F^g,A205^e	V885M^f,g,R927^e	C76^e	None	None	E21Q^g,S95T^g,G668D^f,g	None	L11^e	Q360H^g
Mtb293	E92D^g,S100F^g,A205^e	V885M^f,g,R927^e	C76^e	None	None	E21Q^g,S95T^g,G668D^f,g	None	L11^e	Q360H^g
Mtb940	E92D^g,S100F^g,A205^e	V885M^f,g,R927^e	C76^e	None	None	E21Q^g,S95T^g,G668D^f,g	None	L11^e	Q360H^g
Mtb984	E92D^g,S100F^g,A205^e	V885M^f,g,R927^e	G5S^f,g,C76^e	G406S^d,g	F94S^f,g	E21Q^g,D94G^d,g,S95T^g, G668D^f,g	None	L11^e	Q360H^g
Mtb43	E92D^g,S100F^g,A205^e	V885M^f,g	C76^e	M306V^d,g	T76I^g	E21Q^g,D94G^d,g,S95T^g,G668D^f,g	G1332A,A1401G	L11^e	P164L^f,g,Q360H^g

^a“R”, resistance of isolates to the corresponding anti-TB drug; “S”, sensitivity of isolates to the corresponding anti-TB drug; “del”, deletion; INH, isoniazid; RMP, rifampicin; STR, streptomycin; EMB, ethambutol; PZA, pyrazinamide; OFX, ofloxacin; LVX, levofloxacin; KAN, kanamycin; CAP, capreomycin; AMK, amikacin; ETH, ethionamide.
^bintergenic regions.
^cnucleotide mutational position is relative to Mycobacterium tuberculosis H37Rv rpoB, and amino acid position is relative to Escherichia coli numbering.
^ddrug resistance-asssociated mutations with high confidence.
^esynonymous.
^fnewly identified mutations.
^gnon-synonymous.

ISSN: 1471-2164