Table 5 Ariadne pathways based on ISACHC2-specific genes differentially regulated in dogs with ISACHC2 heart failure
From: The transcriptomic profile of peripheral blood nuclear cells in dogs with heart failure
Ariadne receptor signaling pathways | The number of genes | p-value |
|---|---|---|
UrokinaseR - > ELK-SRF signaling | 9 | 0.0010517 |
IL4R - > ELK-SRF/HMGY signaling | 9 | 0.00118083 |
PDGFR - > FOXO3A signaling | 5 | 0.00176524 |
IL2R - > ELK-SRF/MYC signaling | 8 | 0.00234544 |
AGER - > NF-kB signaling | 6 | 0.00241572 |
IL15R - > NF-kB/NFATC signaling | 6 | 0.0028208 |
IL7R - > FOXO/NF-kB signaling | 6 | 0.00327501 |
InsulinR - > CTNNB/FOXA/FOXO signaling | 5 | 0.0038699 |
FibronectinR - > CTNNB signaling | 6 | 0.00434523 |
TNFRSF5/13B - > NFATC1 signaling | 5 | 0.00459712 |
VEGFR - > CTNNB signaling | 5 | 0.00459712 |
PTPRC - > STAT6 signaling | 2 | 0.00520887 |
FGFR - > AP-1/CREB/CREBBP/ELK-SRF/MYC signaling | 10 | 0.00699557 |
HGFR - > FOXO3A signaling | 4 | 0.00709744 |
AdenosineR - > NF-kB signaling | 7 | 0.0071087 |
ErythropoietinR - > FOXO3A signaling | 4 | 0.00859443 |
TLR3 - > NF-kB signaling | 3 | 0.00948063 |
ICAM2 - > CTNNB/FOXO/STAT3 signaling | 5 | 0.00974526 |
CD19 - > NF-kB signaling | 5 | 0.00974526 |
InsulinR - > ELK-SRF/SREBF signaling | 7 | 0.0104641 |
FibronectinR - > AP-1/ELK-SRF/SREBF signaling | 10 | 0.0106044 |
Notch - > NF-kB signaling | 5 | 0.0111183 |
GHR - > NF-kB signaling | 5 | 0.0111183 |
IL12R - > NF-kB/NFATC signaling | 5 | 0.0126187 |
DopamineR2 - > NF-kB signaling | 5 | 0.0126187 |
ThrombinR - > NF-kB signaling | 5 | 0.0126187 |
ErythropoietinR - > NF-kB signaling | 6 | 0.0138912 |
AGER - > CREB/SP1 signaling | 5 | 0.0142517 |
AngiopoietinR - > FOXO signaling | 4 | 0.0142826 |
VEGFR - > FOXO3A signaling | 4 | 0.0166053 |
CholinergicRm - > CREB/ELK-SRF signaling | 10 | 0.0174704 |
B-cell receptor - > NFATC signaling | 5 | 0.0179347 |
ErythropoietinR - > AP-1/CREB/MYC signaling | 8 | 0.0182859 |
EDG2 - > ELK-SRF signaling | 7 | 0.0189356 |
SerotoninR1 - > FOS signaling | 10 | 0.019617 |
HGFR - > AP-1/CREB/MYC signaling | 8 | 0.0209776 |
IGF1R - > CEBPA/FOXO1A signaling | 4 | 0.0219319 |
FcIgER - > ELK-SRF signaling | 7 | 0.0220582 |
TLR1/2/6 - > NF-kB signaling | 5 | 0.0222033 |
DopamineR2 - > AP-1/CREB/ELK-SRF signaling | 9 | 0.024631 |
GDNF - > HSF1 signaling | 7 | 0.025526 |
ThrombopoietinR - > AP-1/CREB/ELK-SRF/MYC signaling | 8 | 0.0255337 |
VEGFR - > AP-1/CREB/MYC signaling | 8 | 0.0289362 |
MacrophageR - > CEBPB/NF-kB signaling | 5 | 0.0326186 |
TLR3 - > IRF signaling | 2 | 0.0326546 |
FibronectinR - > NF-kB signaling | 6 | 0.032985 |
GHR - > ELK-SRF/MYC signaling | 6 | 0.0355346 |
B-cell receptor - > NF-kB signaling | 6 | 0.0382096 |
CholinergicRn - > CREB signaling | 5 | 0.0388136 |
NTRK - > FOXO/MYCN signaling | 4 | 0.0394373 |
EGFR - > AP-1/CREB/ELK-SRF/MYC signaling | 8 | 0.0410289 |
IL6R - > STAT signaling | 2 | 0.0423644 |
PDGFR - > AP-1/MYC signaling | 7 | 0.043159 |
CD38 - > NF-kB signaling | 7 | 0.043159 |
KIT - > MITF signaling | 6 | 0.043943 |
NTRK - > AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | 8 | 0.0457237 |
PTAFR - > AP-1/ATF1/CREB/ERK-SRF signaling | 9 | 0.0466592 |
IGF1R - > MEF/MYOD/MYOG signaling | 6 | 0.0470043 |
CD19 - > AP-1/ELK-SRF signaling | 6 | 0.0470043 |
PTAFR - > NF-kB signaling | 6 | 0.0470043 |
ThrombopoietinR - > SPI1 signaling | 4 | 0.0481701 |