Supplemental carnitine affects the microRNA expression profile in skeletal muscle of obese Zucker rats

BMC Genomics

Table 1 Most strongly up-regulated (log2 Ratio ≥ 0.5) and down-regulated (log2 Ratio ≤ −0.5) miRNAs in skeletal muscle of Zucker rats by supplemental carnitine

ProbeID	Annotation	Log2 Ratio	FC	P-value*
Up-regulated miRNAs
148278	Rno-miR-138-2-3p	0.68	1.61	0.023
10925	Rno-miR-10b-5p	0.65	1.57	0.023
148261	Rno-miR-208a-5p	0.60	1.51	0.027
14285	Rno-miR-487b-3p	0.60	1.51	0.023
11024	Rno-miR-223-3p	0.59	1.51	0.023
11246	Rno-miR-434-3p	0.54	1.45	0.049
27536	Rno-miR-190a-5p	0.54	1.45	0.033
19596	Rno-miR-30d-5p	0.52	1.43	0.027
42763	Rno-miR-347	0.52	1.43	0.023
148059	Rno-miR-493-5p	0.51	1.43	0.023
145638	Rno-miR-29a-5p	0.51	1.43	0.023
42866	Rno-miR-451-5p	0.51	1.42	0.037
148417	Rno-miR-1188-3p	0.51	1.42	0.023
42472	Rno-miR-190b-5p	0.50	1.42	0.023
Down-regulated miRNAs
42586	Rno-miR-466c-5p	−0.51	−1.42	0.023
42462	Rno-miR-883-5p	−0.51	−1.43	0.023
148483	Rno-miR-466b-1-3p	−0.55	−1.46	0.023
148583	Rno-miR-3584-3p	−0.62	−1.54	0.041
42770	Rno-miR-665	−0.64	−1.55	0.027
148139	Rno-miR-3596c	−0.73	−1.66	0.027
17896	Rno-miR-21-3p	−0.78	−1.72	0.023

*P-values have been corrected for multiple testing by the Benjamini and Hochberg adjustment method.

ISSN: 1471-2164