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Table 2 Gene ontology analysis of CG-1521-resistant strains using DAVID bioinformatics

From: High throughput screening identifies modulators of histone deacetylase inhibitors

Gene ontology analysis: resistant strains

Category (GO-FAT)

p-value

Corrected

p-value

Represented strains

tRNA Modification

GO:0006400

2.2E-4

1.1E-2

7

   tRNA Wobble Uridine Modification

GO:0002098

6.9E-7

3.2E-4

7

Transcription

GO:0006350

1.1E-2

0.19 †

15

   Regulation of Transcription, DNA-dependent

GO:0006355

2.9E-6

6.6E-4

20

   Negative Regulation of Transcription

GO:0045892

6.5E-5

5.9E-3

11

   Regulation of Transcription from RNA Pol II Promoter

GO:0006357

2.4E-5

2.7E-3

14

   Srb Mediator Complex

GO:0016592

1.1E-5

1.7E-3

6

  1. Eighty resistant strains were identified in the yeast gene deletion library screen. Reported p values have been corrected using the methods described by Benjamini and Hochberg. The GO FAT database, developed as part of DAVID, removes very broad GO terms and comprises more specific terms [28, 29]. †Corrected p-values not significant.
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BMC Genomics

ISSN: 1471-2164

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