Figure 4
From: Chromosome-breakage genomic instability and chromothripsis in breast cancer
Chromosome-breakage instability reveals additional complexity of breast cancer genome when shown at the level of individual chromosomes. The instability at the level of individual chromosomes is shown for two tumors with very similar BPI. If looking at instability as proportion of chromosome altered (A) the pattern of instability is very different than that derived from the number of breakpoints per chromosome (B). Views of array CGH data for chromosome 8 in specimen T117 and T199, with aberrations identified with ADM-2 algorithm (shaded areas) showing that Chromosome 8 in tumor T199 is particularly aberrant/broken (C).