Chromosome-breakage genomic instability and chromothripsis in breast cancer

BMC Genomics

Table 3 Summary of clinical data for all tumors

Clinical subtype	Tumor number	Age	T	N	Stage	Grade	ER	PR	HER2+	Recurrence type	DSF (months)	OV (months)	Last follow (months)	BPI	Chromothripsis	Ploidy
ER+	39	72	2	1	2	2	+	+	na	Lung	126		132	25		D/T
	61	61	2	1	2	2	+	+	-	Bone	17		116	30	Yes	D/T
	274	61	3	3	3	na	+	+	-	Liver, bone	35	35		59		D/T
	23	37	4	1	3	1	+	+	na	Bone	57	90		69	Yes	A
	55	52	2	1	2	2	+	+	na	Lung	58	66		91		A
	268	71	2	na	2	2	+	+	-	Liver, bone	45	52		121		A
	46	51	3	2	3	na	+	-	na	Metastasis	23	31		139	Yes	A
	147	32	1	1	2	2	+	+	-	Bone, liver	35	91		434	Yes	D/T
HER2+	333	48	2	0	2	3	-	+	+				18	64	Yes	A
	260	44	3	0	2	2	+	-	+				56	82		A
	70	49	2	1	2	3	-	+	+	Bone, liver	12	35		136		A
	111	44	1	0	1	2	-	-	+	Liver, lung, bone, brain	20	39		141	Yes	A
	207	43	1	0	1	2	-	-	+				43	162	Yes	A
	155	58	1	1	2	3	-	-	+	Brain, bone, liver	26	28		187		A
	74	36	2	1	2	2	+	+	+	Bone	91		110	215	Yes	A
	64	70	2	2	3	3	-	-	+				91	329	Yes	A
	214	38	1	0	1	2	+	+	+				89	557		A
TNBC	190	72	2	0	2	2	-	-	-	Lung, lymph nodes	98		125	35	Yes	T
	253	55	2	0	2	3	-	-	-	Abdomen, lung, bones	71		94	74		T
	117	47	3	2	3	3	-	-	-	Skin, lung	8	26		91		A
	199	44	2	0	2	2	-	-	-	Bone	28	29		93	Yes	A
	79	56	1	1	2	3	-	-	-	Bone, lung	9	29		104	Yes	A
	57	34	1	0	1	3	-	-	-				97	105		A
	221	69	2	2	3	na	-	-	-				61	122		D
	25	45	2	2	3	2	-	-	-				127	150		A
	76	43	1	0	1	3	-	-	-				97	152		D
	52	54	2	0	2	2	-	-	-				85	264		A
	210	45	1	1	2	2	-	-	-	Brain, lung, liver, bone	18	35		309		A
	222	41	2	0	2	3	-	-	-	Brain, bone, liver	17	22		714		A

Abbreviations in the table: T tumor size category, N lymph node status (number of positive nodes), ER estrogen receptor status, PR progesterone receptor status, HER2 HER2 receptor status, DSF disease free survival (given for the patients who relapsed), OV overall (given for the patients who died), BPI breakpoints instability index.

ISSN: 1471-2164