Figure 1

Generation of a beta cell reporter mouse that faithfully and selectively marks all beta cells. A fusion of histone-2b (H2b) and monomeric cherry (mCherry) was inserted downstream of the long Ins1 promoter fragment (A) to generate a mIns1-H2b-mCherry beta cell reporter mouse that features nuclear expression of mCherry in all beta cells (B). Male (C) and female (D) mIns1-H2b-mCherry mice demonstrate normal glucose control as demonstrated by glucose tolerance test compared to wild type littermates.