Figure 4
From: Differential motif enrichment analysis of paired ChIP-seq experiments
TRE and CRE motifs near promoters bound by FOS in untreated MCF10A-ER-Src cells. The CentriMo plots show the distribution of a known motif for the ChIP-ed TF around TSSs that are near (≤1000 bp) a FOS ChIP-seq peaks (solid curve) or more distal (dotted curve). The plots are centered on the TSS. Panel A shows the motif (a CRE motif) with most significant differential local enrichment (Fisher E-value =1.4·10-10); panel B shows the third most locally enriched motif (a TRE motif) around FOS-bound promoters (non-differential E-value =1.4·10-52. Motif IDs and the p-value of the motif’s local enrichment near the FOS-bound promoters is shown in the legend of each plot.