Figure 5

Correlation between Child-Pugh score and the signal intensity of functional genes. Seven genes correlated negatively with the severity of liver disease, as estimated by the Child-Pugh score, including genes for genes for carbohydrate metabolism (transaldolase) (Figure 5A), glycan metabolism (phospho-N-acetylmuramoyl-pentapeptide transferase gene) (Figure 5B), amino acids synthesis (aspartate-ammonia ligase, serine-tRNA ligase and glutamate decarboxylase A and B PLP-dependent gene) (Figure 5C, D, and E), and nucleotide metabolism (IMP dehydrogenase gene and adenylosuccinate synthetase gene) (Figure 5F, G). The gene name is on the top of each figure, with the functional category name in brackets. The Spearman Rank correlation (r) and probability (p) with Bonferroni correction was used to evaluate statistical importance.