Table 4 Functional studies of candidate genes
Gene symbol | Caspase-3/7 activity | Cancer-related Cignal Reporter Array | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Wnt (TCF/LEF) | Notch (RBP-Jκ) | p53/DNA damage (p53) | TGFβ (SMAD2/3/4) | cell cycle (E2F/DP1) | NFκB (NFκB) | c-Myc (Myc/Max) | Hypoxia (HIF1A) | MAPK /ERK (Elk-1/SRF) | MAPK /JNK (AP-1) | ||
PIGB | Decrease | No | No | No | No | No | Decrease | Decrease | No | Decrease | Decrease |
ZADH2 | Decrease | No | No | No | No | No | No | Increase | No | No | No |
PSME3 | Decrease | No | Increase | No | Decrease | No | No | Increase | Decrease | No | No |
DOK6 | Decrease | No | No | No | No | No | Decrease | No | No | No | Decrease |
TGFBI | Decrease | No | No | Increase | No | No | Decrease | Decrease | Decrease | Decrease | Decrease |
C14orf169 | Decrease | No | Increase | Increase | No | No | Increase | Increase | No | Increase | Increase |
TUSC3 | Decrease | No | No | No | Decrease | Decrease | No | No | Decrease | No | No |
RIS1 (TMEM158) | No | No | No | No | No | No | No | Increase | No | No | No |
LNX2 | No | No | No | No | No | No | No | No | No | Increase | No |
SMC2 | No | No | No | No | No | No | No | No | No | No | No |
HLA-DRA | Decrease | No | Increase | No | No | No | Increase | No | No | No | No |