Table 2 Candidate RIF resistance compensatory mutations found in RpoA, RpoB, and RpoC among RIF-resistant isolates with other RIF resistant associated mutations in RpoB
Protein | Mutation | SCG | No. of Isolates | SIFT Score |
|---|---|---|---|---|
RpoA | E184D | 2 | 1 | 0.09 |
RpoB | P45A | 5 | 1 | 0.01 |
RpoB | T328N | 2 | 1 | 0.03 |
RpoB | L452P | 5 | 2 | 0.00 |
RpoB | V496A | 6a | 1 | 0.10 |
RpoB | D634G | 5 | 1 | 0.49 |
RpoB | L731P | 2, 5 | 13 | 0.00 |
RpoB | E812G | 2 | 1 | 0.08 |
RpoB | I1106T | 5 | 2 | 0.00 |
RpoC | G442C | 5 | 1 | 0.00 |
RpoC | W484G | 2 | 1 | 0.00 |
RpoC | D747G | 4 | 1 | 0.35 |
RpoC | K1152Q | 5 | 4 | 0.00 |
RpoC | S1287L | 6a | 1 | 0.23 |