Figure 5
From: The structural network of Interleukin-10 and its implications in inflammation and cancer
E41* nonsense mutation on IL-10RB protein. IL-10 (2ilkA) is shown in green, blue protein is IL-10RB (3lqmA) and the yellow segment is the deleted part in E41* nonsense mutant of IL-10RB. This mutation causes the loss of a large part of the protein, including most of the interface between IL-10 and IL-10RB, so that it blocks the interaction of IL-10RB with IL-10. If IL-10 cannot interact with its receptors, downstream signaling does not take place and anti-inflammatory outcomes of IL-10 pathway will be lost, allowing inflammation to develop.