Figure 7
From: The structural network of Interleukin-10 and its implications in inflammation and cancer
IL-10 (2ilk, green) is predicted to bind to A2M (1bv8, purple) with a binding energy score of -39.2. The template interface is 1mwqAB, a hypothetical protein from H. influenzae with a putative active-site phosphohistidine. The yellow segment is the deleted part of IL-10 due to Q56* nonsense mutation. The deleted part includes the interface region, so the interaction between IL-10 and A2M is disrupted.