Figure 4

Difference in ratio above and below various thresholds for inversely correlated genes. Figure showing the difference in ratio of inversely correlated genomic regions (methylation ↑ expression ↓ and vice versa) above and below varying thresholds. Only regions having differential methylation FDR<0.01 are included. Results contain analysis for Batch230, Batch250 and pooled dataset separately. Considering all three datasets, best performing threshold with highest difference between above and below threshold is 15%. Hence, including threshold of 15% methylation level change in the analysis may improve the knowledge of disease aetiology.