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Table 2 Area under the curve (AUC) of ROC in different background conditions (low, intermediate or high levels of non-exonic mapped reads) using DESeq and XBSeq, when comparing 3 or 6 replicates in each test group.

From: Differential expression analysis of RNA sequencing data by incorporating non-exonic mapped reads

 

DESeq

Different background levels

XBSeq

Different background levels

Replicates per group

Low

Intermediate

High

Low

Intermediate

High

3

0.69

0.66

0.64

0.82

0.78

0.72

6

0.76

0.73

0.70

0.89

0.86

0.80

  1. Overall, XBSeq outperforms DESeq, on average in terms of AUC, by 0.11 and 0.12 for 3 and 6 replicates per group, respectively.