Table 3 WDR genes associated with human disease and their Arabidopsis homologs.
Human disease | Human gene and function | Arabidopsis gene(s), expect (E) value, and function if known |
|---|---|---|
Chediak-Higashi syndrome (CHS) [85] | LYST (ENSG00000143669) involved in protein trafficking [86] | At4g02660 (3E-98) At1g03060 (3E-85) |
sensorineural deafness [87] | TBL1 (ENSG00000092377) component of SMRT and NCOR corepressor complexes [88] | At5g67320 (1E-104) |
Cockayne's syndrome [89] | CSA (ENSG00000049167) transcription-coupled DNA repair [89] | At1g27840 (6E-55) At1g19750 (2E-33) |
Triple-A syndrome (AAAS) [90] | ALADIN (ENS00000094914) nucleoporin [9] | At3g56900 (1E-29) |
Refsum disease, rhizomelic chondrodysplasia punctata (RCDP) [91] | PEX7 (ENSG00000112357) peroxisomal receptor for type-2 peroxisomal targeting signals [92] | PEX7/At1g29260 (2E-74) Peroxisomal receptor for type-2 peroxisomal targeting signals [73] |