Table 2 Cancer related pathologs. Representative disease is shown for each clone. * RTPS6.3 (representative transcript protein set 6.3) cluster representative transcriptional unit (TU) of the FANTOM2 clone set. OMIM status: 1 = gene present in OMIM with a reported disease; 2 = gene present in OMIM with different disease association or without disease; 3 = gene not present in OMIM.

CANCER

    Diagnosis

1110013A16*

AK003650

Squamous cell carcinoma antigen 2

Squamous cell carcinoma

1

1300012C15*

AK004970

Cargo selection protein tip47

Gynecologic malignancies

2

1600002M22*

AK005400

Pregnancy-specific beta 1-glycoprotein

Trophoblastic disease, tumour marker

1

1810011L16*

AK007436

Adamts-9 precursor

Hereditary renal tumors

3

2310046E09

AK009843

Pancreatic secretory granule membrane major glycoprotein gp2 precursor

Chronic lymphocytic leukemia

2

2600013I19*

AK011199

Diphthamide biosynthesis protein-2

Prognosis of neoplastic diseases

2

4631401E18*

AK019470

Udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyl Transferase 7

Colorectal carcinoma

2

4930435F02

AK019597

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Breast cancer

3

4932411D20*

AK029960

Ctcl tumor antigen se2-2

T-cell based immunotherapy

3

5330423N11*

AK077331

Melastatin 2

Cutaneous malignant melanoma

3

9130023H10*

AK033603

Mlze

Melanoma

3

9130413M24*

AK078964

Ctcl tumor antigen se57-1

T-cell based immunotherapy

3

9330156N18*

AK034104

Desmoglein 1 precursor

Paraneoplastic pemphigus

2

A030012E10*

AK037235

Serine protease desc1 precursor

Squamous cell carcinoma

3

A230060D07*

AK038754

Reverse transcriptase-like protein

Chronic myelogenous leukemia

3

A430037M23

AK039975

Dipeptidyl-peptidase iii

Endometrial neoplasms

2

A630051G17

AK080312

Meningioma-expressed antigen 6/11

Meningioma and glioma

1

E130307D12*

AK087504

Scaffold attachment Factor b

Breast cancer

1

G430124K07*

AK090101

Restricted expression proliferation associated protein 100

Lung carcinoma

3

    Pathophysiology

0610006O14

AK002260

Vacuolar proton-atpase subunit atp6h

Melanoma

2

0610008P16*

AK002360

Hp33 protein

Hepatocellular carcinoma

3

1110068E08*

AK004405

Ku70-binding protein

Gliomas

3

1200003O15*

AK004587

Proto-oncogene tyrosine-protein kinase fes/fps

Leukaemia

1

1500012D09

AK005230

Ras-related protein rab-2

Nasopharyngeal carcinoma

1

1700001P03*

AK005620

Homeobox transcription factor

Colon cancer

1

1700006L01

Smac protein, mitochondrial precursor

Multiple myeloma

2

1700012B18*

AK005892

Pregnancy-induced growth inhibitor

Breast cancer

3

1700045I19*

AK006700

Hsd-4 protein

Prostate cancer

2

1810017F10*

AK007525

Beta-casein-like protein

Tumour-associated antigen

3

2010003F10*

AK008064

Transmembrane 4 superfamily, member 5

Pancreatic cancer

1

2210006M16*

AK008663

Gasdermin

Human gastric cancer cells

3

2210007N23

AK019050

Ca11 protein homolog

Gastric carcinogenesis

1

2210412D05

AK008907

Rho guanine nucleotide exchange factor 5

Acute myeloid leukaemia

1

2210414K06

AK008928

Nesh

Cell metastasis and malignant transformation

2

2310016C08*

AK009377

Hypoxia-inducible protein 2

Cervix cancer

3

2510002J07*

AK010891

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

Cancers and inflammation-associated diseases.

2

2610002I10

AK011289

C-myc target jpo1

Tumourigenesis

3

2610005L07

AK011323

Cadherin

Cancer development

1

2700048G21*

AK012392

Antigen ny-co-8

Colon cancer antigen

3

2810411G23

AK013085

Tumor protein d54

Breast cancer

1

2810425C21*

AK013153

Death domain of death-associated protein kinase 1

Non-small cell lung cancer

2

2810449N18*

AK013316

Sirtuin 6

Thyroid carcinoma

2

2900009D12

AK013503

Succinate dehydrogenase

Hereditary paraganglioma

1

4432412E01*

AK014491

X-ray repair cross-complementing protein 3

Bladder-cancer

2

4631410F01

AK028459

Adamts-12 precursor

Gastric carcinomas

3

4732440A06*

AK028704

Calcium-activated chloride channel-2

Breast cancer, metastasis

2

4930500E24*

AK019661

Gas-2 related protein on chromosome 22

Central nervous system tumours

3

4932436B18*

AK030081

Pms1 protein homolog 1

Prostate cancer

1

4933405E14*

AK016662

Serologically defined colon cancer antigen 1

Tumour suppressor

3

4933409E02*

AK016751

Retinoblastoma-associated protein rap140

Colon cancer cell line

3

5430417G24*

AK030670

Headpin serine proteinase inhibitor

Squamous cell carcinoma

1

5630400A09*

AK030708

P63 protein

Basal cell and squamous cell carcinomas

1

5730484M20*

AK077629

Cell cycle checkpoint protein chfr

Lung cancer

1

6430531D06*

AK032385

Elks

Capillary thyroid carcinoma

1

6430587E11

AK032541

Copine vii

Breast cancer

1

6820401K01*

AK033012

Npat

Cancer development

2

9330137N20

AK079068

Hepatic leukemia factor

Lymphoblastic leukaemia

1

9330200A01*

AK034492

Ubiquitin specific protease

Squamous non-small cell lung carcinoma

2

A130080E24*

AK038118

C-myb protein

Colon tumour

3

A430025E01*

AK039888

P68 RNA helicase

Colorectal tumours

2

A430075F05

AK040185

Lipoma preferred partner

Acute myeloid leukaemia

1

A730042E07

AK042943

Serine/threonine protein phosphatase 2a, 72/130 kda regulatory subunit B

Melanoma

2

A830098D13*

AK044188

Megacaryocytic acute leukemia protein, isoform i

Acute megakaryoblastic leukemias

1

A930033B01

AK020920

Graf

Hematopoeitic disorders

1

B130017M24

AK044984

Hepatocellular carcinoma autoantigen

Hepatocellular carcinoma

3

B230314N17

AK045848

Deleted in lung and esophageal cancer 1

Carcinogenesis

1

B930026D14*

AK047144

Myc box dependent interacting protein 1

Prostate carcinoma

3

B930095M03*

AK081171

Frat2

Gastric cancer

1

C130050F24*

AK048341

Ranbp7/importin 7

Colorectal carcinoma

2

C130062I06*

AK048462

Fibrillarin

Hepatocellular carcinoma

1

C230012L01

AK048706

Androgen-induced prostate proliferative shutoff associated protein

Prostate cancer

1

C630001O15

AK049821

Malt1

MALT lymphoma

1

D330038I09

AK052361

10-formyltetrahydrofolate dehydrogenase

Tumour cells

2

E030001H09*

AK086788

Phd finger protein 3

Glioblastoma multiforme

1

E030027H19*

AK087108

Cub domain containing Protein 1

Human colorectal cancer

3

E230037B21

AK054229

Vault poly(adp-ribose) polymerase

Several tumour types

3

F630110I03

AK089273

Matrix metalloproteinase-25 precursor

Colon carcinomas or brain tumours

3

F730035A01

AK089461

Swi/snf complex 170 kda subunit

Malignant rhabdoid tumours

1

G630018E19*

AK090207

Prostate cancer overexpressed gene 1

Prostate cancer

1

G630034H08*

AK090280

Transcriptional repressor scratch

Small cell lung cancer

3

    Treatment

1100001P14

AK075618

Beta-tubulin class iva isotype

Human colon adenocarcinoma

3

1200012D01*

AK004723

Magic roundabout

Angiogenesis

3

1810010L20

AK075773

Pituitary tumor-transforming gene 1 protein-interacting protein

Pituitary adenomas

2

2310039D24*

AK009689

Carboxylesterase

Solid tumours

1

2600009M07

AK011174

Polyamine modulated factor-1

Antineoplastic activity

3

2810459H04

AK013366

Thrombospondin

Angiogenesis

1

3010033I09*

AK019405

Alex1

Tumours originating from epithelial tissue

1

5730405M22*

AK077421

Phosphoprotein enriched in astrocytes 15

Glioma

2

6030493E19

AK031701

Melanoma antigen p15

Melanoma

1

6230424I22*

AK031785

NUCLEAR MATRIX PROTEIN p84

Tumor suppression

2

A730016J02

AK042696

Acetyltransferase tubedown-1

Vascular and haematopoietic development

3

B130023J22

AK045057

Greb1b

Breast cancer

3

C920008O22

AK050594

Retinoblastoma-binding protein 1

Breast cancer

2

D030050C19

AK083587

Chronic myelogenous leukemia tumor antigen 66

Leukemias and tumour cell lines

1

D630010E08*

AK052639

Carbonic anhydrase xii precursor

Cancer tumour cells

1

D830007E07*

AK052857

Inositol hexakisphosphate kinase 3

Ovarian cancer

2