Figure 1

FU gene structure. All sequenced segments of the available FU cDNA clones (1HFU, 2HFU and Ngo3689) were identified in a BAC clone (AC009974) from chromosome 2. This allowed the identification of the exonic sequences and thereby also the introns. The FU protein sequence [8] and translational analysis provided information about the role of different exons. Exons 1 and 2 encode 5'UTRs shown in brown. Exon 3 contains the initiating ATG codon approximately in the middle (position 90–92 from 5'end). Exons 3 to 9 encode the kinase domain shown in red. As judged from the cDNA clones the sequences encoded by exons 8, 13 and part of exon 24 are subjected to alternative splicing. Both exon 13 and 29 encode in frame stop codons. The cDNA clones end with a poly A⁺ tail at the same position starting 706 bp from the stop codon (TGA) in exon 29.