Figure 4

Genome-wide analysis of DNA copy number alteration by A-CGH. Samples were grouped based on sample type, MYCN amplification status and tumor stage. Each column represents a different sample; and each row represents a p-value of a given SW-locus using a sliding window of 40 adjacent clones, ordered in genome order across the whole genome. Black triangles on the right side of image represent centromere positions. Cell-: cell line without MYCN amplification; Cell+: cell line with MYCN amplification; Stage 4-: tumor in stage 4 without MYCN amplification; Stage 4+: tumor in stage 4 with MYCN amplification. On the right is shown an enlarged view of the region around the MYCN gene (2p24) for the amplified NB samples.