Figure 2

Computationally predicted clusters of cis -elements in the promoter region of mouse H2-K and its human ortholog HLA-A: The ATG of human HLA-A is at position 10,001 while that of mouse H2-K is at 10,463. Thus, the region represented relative to ATG is -305 to +97 (human) and -653 to -293 (mouse). Additionally, these regions correspond to chr 6: 30,015,866–30,016,268 (+) of the Human Genome July 2003 Assembly and chr17: 33,638,839–33,639,199 (-) of the Mouse October 2003 Assembly http://genome.ucsc.edu. Families of transcription factor binding sites and the relative positions of the sites in the nucleotide sequences of the two genes are represented as different colored bars stretching across the ortholog gene pair.