Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: The Human GPCR-DB Database

Table 3 SNP distribution in peptide domains.

Peptide domain	Genes	N-term	e-loop	TM	i-loop	c-term	p-value	N-term + e-loop	TM	C-term + i-loop	p-value
Monoamine + Peptide + Chemokines	101	20 (3.7)	17 (3.6)	43 (3.0)	29 (3.5)	27 (4.5)		37 (3.7)	43 (3.0)	56 (4.0)
Monoamine Only	36	7 (5.7)	6 (3.9)	11 (1.9)	16 (3.3)	18 (3.9)	0.26	13 (4.7)	11 (1.9)	34 (3.5)	0.06
Peptide Only	47	10 (2.9)	8 (3.9)	25 (4.2)	11 (4.3)	15 (5.7)	0.89	18 (3.3)	25 (4.2)	26 (5.0)	0.79
Chemokine Only	18	3 (4.0)	3 (2.8)	7 (2.5)	2 (2.5)	4 (4.5)	0.87	6 (3.3)	7 (2.5)	6 (3.5)	0.72
Chemokine + Monoamine	54	10 (5.1)	9 (3.4)	18 (2.1)	18 (3.2)	12 (4.1)	0.93	19 (4.1)	18 (2.1)	30 (3.5)	0.78
Peptide + Monoamine	83	17 (3.7)	14 (3.9)	36 (3.2)	27 (3.6)	23 (4.9)	0.94	31 (3.8)	36 (3.2)	50 (4.2)	0.96
Chemokine + Peptide	65	13 (3.1)	11 (3.5)	32 (3.7)	13 (3.8)	19 (5.4)	0.87	24 (3.3)	32 (3.7)	32 (4.6)	0.71

Total number of nsSNP in various domains of 3 subgroups of GPCR proteins.
Abbreviations: N-term : N terminus; C-term : C terminus; i-loop : internal loops; e-loop : external loops; TM: trans-membrane. The numbers in the brackets are the average number of SNPs per 1000 base pairs of a specific domain. The Fisher's Exact p-values were calculated using a 5 × 2 contingency table at http://home.clara.net/sisa/fiveby2.htm. Contingency tables of 2 × 3 were constructed at http://www.physics.csbsju.edu/stats/contingency.html. P-values of below or close to 0.05 are considered significant.

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