Figure 6

A) Identification of a small globular domain common to the C-termini of TFIIE α subunits of higher eukaryotes and P. falciparum. Top panel: Comparison of the corresponding HCA plots (see figure Fig. 2 for explanation). Cluster similarities are shaded in grey and identities are shown in white on a black background. The position of the globular domain is boxed. Despite the low level of sequence identity, hydrophobic clusters are well conserved, supporting the presence of a common fold. Bottom panel: HCA-deduced 1D alignment. B) Comparison of the TFIIE β subunits of S. cerevisiae, Cryptococcus neoformans and Plasmodia species (P. yoelii and P. falciparum). Cluster similarities are shaded in grey and identities are shown in white on a black background. The deduced 1D alignment is shown at the bottom.