Table 2 Differentially expressed genes from three analyses. ANOVA of xenograft data vs parental cell lines found 149 differential genes (designated ' Ap'), Linear discriminant analysis found 54 genes (designated 'LD') and ANOVA of individual xenograft tumors yielded a consensus of 12 genes (designated 'Ai'). For each gene, its presence is denoted by '1' and its absence noted by '0'. The maximum MANOVA Pvalue is reported along with the aggregate ratio (designated by 'R'). For genes with multiple independent probes, the probe reporting the maximum Pvalue is shown. Seven genes common to all three lists are in bold text.
Ap | LD | Ai | Gene | Pval | R |
|---|---|---|---|---|---|
1 | 1 | 1 | LAMB3 | 0.001 | 1.9 |
1 | 1 | 1 | ANGPTL4 | 0.001 | 2.1 |
1 | 1 | 1 | COL1A1 | 0.001 | 3.6 |
1 | 1 | 1 | PCDHB9 | 0.001 | 4.0 |
1 | 1 | 1 | GPR57 | 0.001 | 5.7 |
1 | 1 | 1 | GP2 | 0.001 | 5.7 |
1 | 1 | 1 | PTGER3 | 0.001 | 6.4 |
1 | 1 | 0 | KITLG | 0.001 | 0.4 |
1 | 1 | 0 | RAP2B | 0.001 | 0.4 |
1 | 1 | 0 | COL5A1 | 0.237 | 1.0 |
1 | 1 | 0 | SEPP1 | 0.054 | 1.0 |
1 | 1 | 0 | CXCL1 | 0.3 | 1.1 |
1 | 1 | 0 | TNC | 0.001 | 1.3 |
1 | 1 | 0 | LTBP1 | 0.009 | 1.3 |
1 | 1 | 0 | PRSS11 | 0.001 | 1.3 |
1 | 1 | 0 | FN1 | 0.008 | 1.4 |
1 | 1 | 0 | FZD1 | 0.019 | 1.4 |
1 | 1 | 0 | SPP1 | 1 | 1.5 |
1 | 1 | 0 | IGFBP7 | 0.001 | 1.7 |
1 | 1 | 0 | RNASE4 | 0.008 | 1.9 |
1 | 1 | 0 | CHODL | 0.003 | 2.1 |
1 | 1 | 0 | NOV | 0.003 | 2.2 |
1 | 1 | 0 | COL12A1 | 0.001 | 2.2 |
1 | 1 | 0 | MAGP2 | 0.001 | 2.6 |
1 | 1 | 0 | GPR23 | 0.574 | 3.0 |
1 | 1 | 0 | TLL1 | 0.001 | 3.2 |
1 | 1 | 0 | GPR44 | 0.069 | 3.6 |
1 | 1 | 0 | MGC2376 | 0.001 | 4.7 |
1 | 1 | 0 | NPY1R | 0.183 | 5.2 |
1 | 0 | 1 | EMP3 | 0.004 | 0.5 |
1 | 0 | 1 | HLA-A | 0.001 | 0.6 |
1 | 0 | 1 | GNAO1 | 0.001 | 2.5 |
1 | 0 | 0 | CCR5 | 0.001 | 0.2 |
1 | 0 | 0 | C20orf52 | 0.001 | 0.4 |
1 | 0 | 0 | SORCS3 | 0.001 | 0.4 |
1 | 0 | 0 | PF4 | 0.005 | 0.4 |
1 | 0 | 0 | SPINK2 | 0.001 | 0.4 |
1 | 0 | 0 | IGSF6 | 0.008 | 0.4 |
1 | 0 | 0 | GPR110 | 0.001 | 0.5 |
1 | 0 | 0 | OR1J5 | 0.001 | 0.5 |
1 | 0 | 0 | BGLAP | 0.001 | 0.5 |
1 | 0 | 0 | GALR2 | 0.001 | 0.5 |
1 | 0 | 0 | HCN2 | 0.001 | 0.5 |
1 | 0 | 0 | CD81 | 0.001 | 0.5 |
1 | 0 | 0 | OGFR | 0.001 | 0.5 |
1 | 0 | 0 | GPR6 | 0.001 | 0.5 |
1 | 0 | 0 | OMP | 0.001 | 0.5 |
1 | 0 | 0 | CMA1 | 0.001 | 0.5 |
1 | 0 | 0 | DKFZP564DO | 0.001 | 0.6 |
1 | 0 | 0 | CHRM1 | 0.001 | 0.6 |
1 | 0 | 0 | PYY | 0.001 | 0.6 |
1 | 0 | 0 | FGF19 | 0.004 | 0.6 |
1 | 0 | 0 | AGTR2 | 0.047 | 0.6 |
1 | 0 | 0 | SSTR3 | 0.001 | 0.6 |
1 | 0 | 0 | TMPO | 0.001 | 0.6 |
1 | 0 | 0 | TAS2R16 | 0.003 | 0.6 |
1 | 0 | 0 | ADORA2B | 0.003 | 0.6 |
1 | 0 | 0 | GPR10 | 0.001 | 0.6 |
1 | 0 | 0 | ADCYAP1R1 | 0.001 | 0.6 |
1 | 0 | 0 | OR1F10 | 0.001 | 0.6 |
1 | 0 | 0 | HDGF | 0.001 | 0.6 |
1 | 0 | 0 | CD151 | 0.001 | 0.6 |
1 | 0 | 0 | PDAP1 | 0.001 | 0.7 |
1 | 0 | 0 | A1BG | 0.001 | 0.7 |
1 | 0 | 0 | LIPF | 0.001 | 0.7 |
1 | 0 | 0 | PBEF | 0.001 | 0.7 |
1 | 0 | 0 | ART-4 | 0.034 | 0.7 |
1 | 0 | 0 | C1QTNF3 | 0.029 | 0.7 |
1 | 0 | 0 | SLC39A4 | 0.022 | 0.7 |
1 | 0 | 0 | IFNGR2 | 0.001 | 0.8 |
1 | 0 | 0 | ENT3 | 0.001 | 0.8 |
1 | 0 | 0 | SERPINC1 | 0.001 | 0.8 |
1 | 0 | 0 | NRP1 | 0.006 | 0.8 |
1 | 0 | 0 | CACNA1H | 0.011 | 0.8 |
1 | 0 | 0 | CD44 | 0.001 | 0.8 |
1 | 0 | 0 | STC2 | 0.018 | 0.8 |
1 | 0 | 0 | DLK1 | 0.064 | 0.8 |
1 | 0 | 0 | F2R | 0.388 | 0.8 |
1 | 0 | 0 | EMP2 | 0.001 | 0.8 |
1 | 0 | 0 | HBE1 | 0.003 | 0.8 |
1 | 0 | 0 | BSG | 0.003 | 0.8 |
1 | 0 | 0 | GPR80 | 0.001 | 0.8 |
1 | 0 | 0 | APOB48R | 0.016 | 0.8 |
1 | 0 | 0 | AMELY | 0.001 | 0.8 |
1 | 0 | 0 | IL26 | 0.006 | 0.8 |
1 | 0 | 0 | TRPM5 | 0.001 | 0.8 |
1 | 0 | 0 | ENSA | 0.001 | 0.8 |
1 | 0 | 0 | OR1F1 | 0.001 | 0.8 |
1 | 0 | 0 | GP3ST | 0.001 | 0.8 |
1 | 0 | 0 | BDNF | 0.001 | 0.9 |
1 | 0 | 0 | PLXN3 | 0.005 | 0.9 |
1 | 0 | 0 | APMCF1 | 0.134 | 0.9 |
1 | 0 | 0 | SCAMP1 | 0.001 | 0.9 |
1 | 0 | 0 | PALMD | 0.001 | 0.9 |
1 | 0 | 0 | MMP8 | 0.02 | 0.9 |
1 | 0 | 0 | MFAP3 | 0.004 | 0.9 |
1 | 0 | 0 | SPAG11 | 0.001 | 0.9 |
1 | 0 | 0 | A2M | 0.031 | 0.9 |
1 | 0 | 0 | NET-2 | 0.092 | 0.9 |
1 | 0 | 0 | CXCL11 | 0.001 | 1.0 |
1 | 0 | 0 | KLRB1 | 0.003 | 1.0 |
1 | 0 | 0 | TF | 0.988 | 1.0 |
1 | 0 | 0 | COL14A1 | 0.001 | 1.0 |
1 | 0 | 0 | IL7 | 0.002 | 1.1 |
1 | 0 | 0 | COL9A1 | 0.001 | 1.1 |
1 | 0 | 0 | CCR4 | 0.001 | 1.1 |
1 | 0 | 0 | FPR1 | 0.034 | 1.1 |
1 | 0 | 0 | FAP | 0.001 | 1.2 |
1 | 0 | 0 | OPCML | 0.001 | 1.2 |
1 | 0 | 0 | GPR145 | 0.001 | 1.2 |
1 | 0 | 0 | GFRA3 | 0.001 | 1.2 |
1 | 0 | 0 | EDN3 | 0.001 | 1.2 |
1 | 0 | 0 | IL12B | 0.043 | 1.3 |
1 | 0 | 0 | CXCR4 | 0.026 | 1.3 |
1 | 0 | 0 | PCSK5 | 0.427 | 1.3 |
1 | 0 | 0 | NID2 | 0.168 | 1.3 |
1 | 0 | 0 | ITGA4 | 0.73 | 1.3 |
1 | 0 | 0 | KIAA1870 | 0.016 | 1.3 |
1 | 0 | 0 | FBLN5 | 0.001 | 1.4 |
1 | 0 | 0 | TRPV2 | 0.001 | 1.4 |
1 | 0 | 0 | FGF23 | 0.119 | 1.4 |
1 | 0 | 0 | TEM5 | 0.001 | 1.4 |
1 | 0 | 0 | CR1 | 0.008 | 1.4 |
1 | 0 | 0 | GPA33 | 0.001 | 1.4 |
1 | 0 | 0 | CLCA4 | 0.001 | 1.4 |
1 | 0 | 0 | TIMP3 | 0.006 | 1.4 |
1 | 0 | 0 | MMP10 | 0.001 | 1.4 |
1 | 0 | 0 | FUT8 | 0.197 | 1.4 |
1 | 0 | 0 | FIBL-6 | 0.001 | 1.4 |
1 | 0 | 0 | V1RL1 | 0.001 | 1.5 |
1 | 0 | 0 | EBI2 | 0.003 | 1.5 |
1 | 0 | 0 | ADAM28 | 0.001 | 1.5 |
1 | 0 | 0 | GPLD1 | 0.008 | 1.5 |
1 | 0 | 0 | CP | 0.003 | 1.5 |
1 | 0 | 0 | EPHA3 | 0.003 | 1.5 |
1 | 0 | 0 | KLK11 | 0.001 | 1.6 |
1 | 0 | 0 | OR7A17 | 0.001 | 1.6 |
1 | 0 | 0 | IFI27 | 0.001 | 1.7 |
1 | 0 | 0 | RNASE6 | 0.003 | 1.7 |
1 | 0 | 0 | SELPLG | 0.001 | 1.7 |
1 | 0 | 0 | CST7 | 0.092 | 1.7 |
1 | 0 | 0 | LEC3 | 0.001 | 1.7 |
1 | 0 | 0 | TSHR | 0.001 | 2.1 |
1 | 0 | 0 | MC2R | 0.001 | 2.1 |
1 | 0 | 0 | SV2 | 0.001 | 2.1 |
1 | 0 | 0 | SERPINA4 | 0.001 | 2.1 |
1 | 0 | 0 | ANGPT2 | 0.003 | 2.2 |
1 | 0 | 0 | LOC84664 | 0.008 | 2.3 |
1 | 0 | 0 | RNASE1 | 0.001 | 2.9 |
0 | 1 | 1 | HAS1 | 1 | 0.3 |
0 | 1 | 0 | SLC16A8 | 1 | 0.4 |
0 | 1 | 0 | CD164 | 1 | 1.0 |
0 | 1 | 0 | FSTL1 | 1 | 1.0 |
0 | 1 | 0 | IL8 | 1 | 1.0 |
0 | 1 | 0 | KTN1 | 1 | 1.0 |
0 | 1 | 0 | RBP4 | 1 | 1.1 |
0 | 1 | 0 | COL5A2 | 1 | 1.1 |
0 | 1 | 0 | TSPAN-3 | 1 | 1.1 |
0 | 1 | 0 | CD63 | 1 | 1.1 |
0 | 1 | 0 | IGFBP3 | 1 | 1.1 |
0 | 1 | 0 | PLEC1 | 1 | 1.1 |
0 | 1 | 0 | CXCL2 | 1 | 1.2 |
0 | 1 | 0 | GPR48 | 1 | 1.2 |
0 | 1 | 0 | FLJ20559 | 1 | 1.2 |
0 | 1 | 0 | LAMB1 | 1 | 1.3 |
0 | 1 | 0 | COL4A1 | 0.994 | 1.3 |
0 | 1 | 0 | TFPI2 | 1 | 1.4 |
0 | 1 | 0 | ESR1 | 0.996 | 1.5 |
0 | 1 | 0 | SLC11A3 | 0.999 | 1.6 |
0 | 1 | 0 | EFNA1 | 1 | 1.6 |
0 | 1 | 0 | KLK13 | 1 | 2.5 |
0 | 1 | 0 | AB065858 | 1 | 3.1 |
0 | 1 | 0 | MMP7 | 0.987 | 3.4 |
0 | 1 | 0 | INHBB | 1 | 3.5 |
0 | 0 | 1 | PI3 | 1 | 0.4 |