Table 2 The genes for which a visible RNAi phenotype or/and a distinct GFP expression in C. elegans and a subcellular protein over-expression profile using human cell lines has been obtained.
From: A combined approach exploring gene function based on Worm-Human Orthology
Worm gene / Human ortholog | RNAi (C. elegans) | GFP expression (C. elegans) | Subcellular localization (human) |
|---|---|---|---|
T24D1.1 / NP_055733 | Smaller population size, sickly appearance, partial sterility, smaller brood size | No specific expression observed | Cloning failed |
F23C8.6 / NP_065145 | Slow growth, uncoordinated behavior, larval arrest | No specific expression observed | Cloning failed |
F38H4.7 / AAK25825 | Wild type | No specific expression observed | Cytoplasmic foci |
C11D2.4 / NP_115683 | Wild type | No specific expression observed | Weak cytoplasmic and nuclear pattern |
F41D9.1 / NP_056520 | Wild type | neural cells in the head, along the neural nerve cord and in the tail | Cytoplasimic/nuclear rim |
ZK795.3 / NP_219484 | Slower growth, sterility, | Spermatheca, hypodermal cells, pharynx, excretory cell and channels | Diffuse nuclear, nucleolar, nuclear foci |
C17E4.3 / NP_848545 | Wild type | Three distinct sheath/socket cells in the head; several cells around the cloaca; pharyngeal muscle cells | Perinuclear/nuclear lamina |
B0379.4a / AAP34400 | Egg-laying deffects | No specific expression observed | Cytoskeletal/plasma membrane |
C09D4.1 /NP_060261 | Wild type | Intestinal cells | Protein not detected |