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Table 3 Differently regulated (p ≤ 0.05) non-SLC transporters with a minimum absolute fold change of four in any pair-wise comparison of adjoining intestinal segments. Bold cases indicate fold changes of five or higher (Means ± SDs, log2 scale, n = 3 or 9, respectively.).

From: Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

Gene Name

D>J

D<J

J>I

J<I

I>C

I<C

SI>C

SI<C

Literaturea

Gene aliases

References

Aldh9a1

    

2.4 ± 0.1

   

-

ESTM40; TMABA-DH

-

Apoc2

  

3.7 ± 0.5

 

2.5 ± 0.5

 

4.9 ± 0.6

 

Mouse: expressed in intestine; Rabbit: expressed in J, D; Human: expressed in J

-

[87-89]

Aqp4

     

4.6 ± 0.8

 

4.3 ± 0.3

Mouse: present in SI in crypt cells, and C in epithelial surface cells; rat: SI, C

MIWC; mMIWC

[90, 91]

Aqp5

2.9 ± 0.4

       

Rat: D only

-

[91]

Aqp8

     

4.8 ± 0.6

 

3.9 ± 0.4

Rat: SI and C

-

[91]

Atp2a3

       

2.1 ± 0.2

Human: C > SI

Serca3; SERCA3b

[92]

Atp7a

2.5 ± 0.5

  

4.0 ± 0.4

    

Human: Highly expressed in D

Mo; br; Blo; I14; blotchy; mottled; MNK; brindled

[93]

Chrna1

2.5 ± 0.4

       

-

Acra; Achr-1

-

Chrne

    

2.0 ± 0.4

   

-

Acre

-

Csng

    

2.0 ± 0.8

   

-

Csn1s2a; Csn1s2b

-

D11Ertd18e

  

4.7 ± 0.5

   

4.7 ± 1.0

 

-

-

-

Fabp1

  

5.2 ± 1.1

 

4.7 ± 1.1

 

8.3 ± 0.10

 

Mouse: D, proximal J>I, nothing in distal I; Human: highest in J, present in D, J, I, C

Fabpl; L-FABP

[94]

Gfpt1

   

2.2 ± 0.4

   

2.4 ± 0.4

Mouse: expressed in SI and C; Human: C > SI

GFA; GFAT; Gfpt; GFAT1

[95, 96]

Gfpt2

      

2.1 ± 0.4

 

Human: SI and C very low expressed

-

[96]

Gria1

2.2 ± 0.5

       

-

Glr1; Glr-1; GluRA; Glur1; HIPA1; GluR-A; Glur-1

-

Grm3

     

2.4 ± 1.2

 

2.3 ± 1.2

-

Gprc1c; mGluR3

-

Gsr

   

2.1 ± 0.3

    

-

Gr1; Gr-1

-

Kcna3

  

2.9 ± 0.6

    

2.0 ± 0.4

-

Mk-3; Kv1.3; Kca1-3

-

Kcnk6

        

Mouse: C > SI

Toss; Twik2;

[97]

Kctd3

 

2.7 ± 1.2

2.7 ± 1.3

     

-

NY-REN-45

-

Pkd2

       

2.4 ± 0.5

-

-

-

Pln

       

2.6 ± 0.5

-

PLB

-

Rbp2

  

2.8 ± 0.2

 

3.0 ± 0.3

 

4.7 ± 0.5

 

-

Rbp-2; Crbp-2; CrbpII

-

Rbp7

    

2.9 ± 0.3

 

2.7 ± 0.3

 

-

CRBP-III

-

Saa3

     

3.5 ± 0.6

 

4.0 ± 0.4

Mouse and Human: Expressed in SI and C

Saa-3

[98]

Stard5

     

2.9 ± 1.0

  

-

D7Ertd152e

-

Stx1b1

    

3.0 ± 1.2

   

-

Stx1bl

-

Trpm7

   

2.0 ± 1.0

    

-

CHAK; PLIK CHAK1; Ltpr7; Ltrpc7;

-

Xdh

      

2.8 ± 0.3

 

Mouse: Strong in SI

Xor; Xox1; Xox-1

[99]

  1. aD = Duodenum, J = Jejunum, I = Ileum, C = Colon, SI = Small intestine, - = No data found in the literature
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