Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes

Table 2 Expression of ASS, CHL1, and FLAP in 2 sets of discordant monozygotic twins relative to expression levels in their respective normal siblings

Gene name	Genbank #	A1	M1	A2	M2
ASS	AA676405	0.65 (0.81)*	-0.13 (0.27)	1.77 (3.04)	0.18 (0.97)
CHL1	H15267	1.60 (1.64)	0.67 (1.39)	1.15 (0.78)	0.95 (0.60)
FLAP	T49652	0.71 (1.10)	0.13 (0.77)	1.40 (1.45)	-0.09 (-0.39)

Values are mean log₂(ratio) measures of gene expression between a twin and his respective normal sibling, obtained by DNA microarray analyses with dye reversal replicates
* Values in parentheses are mean log₂(ratio) measures obtained by triplicate qPCR analyses.
A = autistic twin as diagnosed by ADI-R scoresheet
M = more mildly affected twin who did not meet ADI-R criteria for autism

ISSN: 1471-2164