Figure 5From: Topology and weights in a protein domain interaction network – a novel way to predict protein interactionsStatistics of predicted interactions in Plasmodium (a). In each bin, we calculated the mean expectation value of domain interactions that govern the underlying protein interactions. In particular we obtain a significant correlation (r = 0.22, P < 10-5, ρ = 0.34, P < 10-5). Error bars correspond to standard deviations in each bin. (b) In the same way, we calculated the mean functional homogeneity, a measure that reflects the probability that GO terms of interacting proteins are similar. In particular, we find a statistically significant correlation (r = 0.45, P < 10-5, ρ = 0.52, P < 10-5). (c) Determining the frequency of interactions which are fully conserved in the organisms S. cerevisiae, D. melanogaster and H. sapiens we find a strong tendency toward evolutionary conservation of predicted interactions with elevated level of confidence.Back to article page