Figure 4

Two-dimensional cluster diagram of the 1210 signature genes characterizing the luminal A and basal-like subtypes. ANOVA analysis was performed on 6 luminal A samples and 6 basal-like samples, coupled with Benjamini and Hochberg False Discovery Rate multiple testing corrections. The two subtypes of breast tumors (two replicates per sample) were clustered into distinct clusters with reversed gene expression patterns: highly expressed in luminal A (bottom, 613 probes representing 603 genes) and highly expressed in basal (top, 631 probes representing 607 genes). The color scheme of the heat map was described in legend to Figure 1B and is shown in the key. Branches in the dendrogram are color-coded according to the subtypes: blue, luminal A; red, basal-like.