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Table 2 HSP90 family of genes present on the genomes of 32 species, and their chromosomal location, intron/exon structure, molecular mass, signal peptide and prediction of genes that are functional.

From: Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

Gene namea

Accession numberb

Chrom. locationc

Exon nod

a.a.lengthe

Mass (kDa)f

Functiong

 

mRNA

a.a.

     

ARCHAEA

       

Methanosarcina mazei

       

(MMA)NP_634445.1

NC_003901.1

NP_634445.1

N/A+

1

982

114.6

F

BACTERIA

       

Streptomyces coelicolor

       

(SCO)HTPG1

NC_003888.3

NP_631561.1

N/A+

1

638

71.6

F

(SCO)HTPG2

NC_003888.3

NP_625688.1

N/A-

1

615

66.7

F

Bacteroides fragilis

       

(BFR)HTPG1

NC_006347.1

YP_099692.1

N/A-

1

681

78.0

F

(BFR)HTPG2

NC_006347.1

YP_097520.1

N/A+

1

588

67.3

F

Gloeobacter violaceus

       

(GVI)HTPG1

NC_005125.1

NP_924760.1

N/A+

1

614

70.3

F

Bacillus subtilis

       

(BSU)HTPG1

NC_000964.2

NP_391861.1

N/A-

1

626

72.3

F

Wolbachia endosymbiont

       

(WEN)HTPG1

NC_002978.6

NP_966987.1

N/A+

1

635

72.7

F

Bordetella pertussis

       

(BPE)HTPG1

NC_002929.2

NP_878979.1

N/A+

1

635

71.2

F

Geobacter sulfurreducens

       

(GSU)HTPG1

NC_002939.4

NP_953436.1

N/A+

1

650

73.7

F

Helicobacter pylori

       

(HPY)HTPG1

NC_000921.1

NP_222917.1

N/A+

1

621

71.1

F

Escherichia coli

       

(ECO)HTPG1

NC_000913.2

NP_415006.1

N/A+

1

624

71.4

F

Borrelia burgdorferi

       

(BBU)HTPG1

NC_001318.1

NP_212694.1

N/A-

1

650

75.4

F

FUNGI

       

Saccharomyces cerevisiae

       

(SCE)HSP90A1

K01387.1

AAA02743.1

16-

1 (1)

709

81.4

F

(SCE)HSP90A2

M26044.1

AAA02813.1

13+

1 (1)

705

80.9

F

Cryptococcus neoformans

       

(CNE)HSP90A1

XM_568451.1

XP_568451.1

13-

6

700

79.3

F

(CNE)HSP90B1

XM_571124.1

XP_571124.1

5+

11

758 (780, H)

85.5 (87.8)

F

Encephalitozoon cuniculi

       

(ECU)HSP90A1

NC_003229.1

NP_584635.1

2+

1

690

79.0

F

Neurospora crassa

       

(NCR)HSP90A1

AABX01000271.1

EAA32062.1

5+

2

705

80.2

F

PROTISTA

       

Plasmodium falciparum

       

(PFA)HSP90A1

NC_004328.1

NP_704028.1

7+

2

745

86.2

F

(PFA)HSP90B1

NC_004316.1

NP_701576.1

12-

1

793 (821, H)

91.6 (95.0)

F

Dictyostelium discoideum

       

(DDI)HSP90A1

AAFI01000009.1

EAL73152.1

1-

3

700

79.9

F

(DDI)HSP90B1

AAFI01000066.1

EAL67255.1

3-

2

739 (767, H)

84.1 (87.1)

F

Entamoeba histolytica

       

(EHI)HSP90A1

AAFB01000333.1

EAL47778.1

(Sca 00092+)

1

718

83.0

F

(EHI)HSP90A2

AAFB01000334.1

EAL47746.1

(Sca 00092+)

1

718

83.0

F

(EHI)HSP90A3

AAFB01000781.1

EAL44230.1

(Sca 00284+)

2

702

81.1

F

(EHI)HSP90B1

AAFB01000726.1

EAL44584.1

(Sca 00256-)

1

695 (711, H)

79.5 (81.2)

F

Trypanosoma cruzi

       

(TCR)HSP90A1

AAHK01000382.1

EAN93041.1

N/A

1

704

80.7

F

(TCR)HSP90A2

AAHK01000690.1

EAN89940.1

N/A

1

704

80.7

F

(TCR)HSP90A3

AAHK01002401.1

EAN82629.1

N/A

1

704

80.7

F

(TCR)HSP90B1

AAHK01000131.1

EAN96800.1

N/A

1

740 (762, H)

84.7 (87.0)

F

PLANTAE

       

Arabidopsis thaliana

       

(ATH)HSP90A1

NM_124642.2

NP_200076.1

5+

4 (4)

705

81.2

F

(ATH)HSP90A2

NM_124985.3

NP_200414.1

5-

3 (3)

699

80.1

F

(ATH)HSP90A3

NM_124983.3

NP_200412.1

5+

3 (3)

699

80.0

F

(ATH)HSP90A4

NM_124982.2

NP_200411.1

5+

3 (3)

699

80.1

F

(ATH)HSP90B1

NM_118552.2

NP_194150.1

4-

15 (15)

800 (823, H)

91.5 (94.2)

F

(ATH)HSP90C1

NM_126439.2

NP_178487.1

2+

19 (19)

756 (780, H)

86.2 (88.7)

F

(ATH)HSP90C2

NM_111656.2

NP_187434.1

3+

21 (21)

778 (803, H)

88.2 (91.0)

F

Oryza sativa

       

(OSA)HSP90A1P

XM_483191.1

XP_483191.1

8-

3

699

80.2

F

(OSA)HSP90A2P

XM_470993.1

XP_470993.1

4+

3

703

80.2

F

(OSA)HSP90A3P

AP005392.3

BAD33406.1

9-

1

699

80.2

F

(OSA)HSP90A4P

AP005392.3

BAD33409.1

9-

1

699

80.2

F

(OSA)HSP90A5PNP

(OSA)HSP90A5NN*

(OSA)HSP90A5PN*

9-

1

437*

 

P

(OSA)HSP90B1

AB037681.1

BAA90487.1

6-

15 (15)

791 (810, H)

90.6 (92.8)

F

(OSA)HSP90C1

XM_483065.1

XP_483065.1

8-

19 (19)

763 (785, H)

86.3 (88.3)

F

(OSA)HSP90C2

AK073817.1

(OSA)HSP90C2PN

9-

14 (17)

785 (811, H)

89.0 (91.5)

F

Chlamydomonas reinhardtii

       

(CRE)HSP90A1

Schroda (2004)

 

(Sca 2397)

8

705

80.7

F

(CRE)HSP90B1

Schroda (2004)*

 

(Sca 2084, 1758)

≥11

736*

 

F

(CRE)HSP90C1

AY705371.1

AAU10511.1

(Sca 6)

10

756 (810, H)

84.2 (89.3)

F

INVERTEBARATE

       

Drosophila melanogaster

       

(DME)HSP90A1

NM_079175.2

NP_523899.1

3L+ 63B11

1 (2)

717

81.9

F

(DME)HSP90B1

NM_143344.2

NP_651601.1

3R+ 98B6

5 (5)

767 (787, H)

88.1 (90.2)

F

(DME)TRAP1

NM_058091.3

NP_477439.2

2R- 42C1

3 (3)

673 (691, N)

74.7 (78.0)

F

Drosophila pseudoobscura

       

(DPS)HSP90A1P

NM_079175.2

NP_523899.1

XR-

1

717

81.8

F

(DPS)HSP90B1P

CM000070.1

EAL27390.1

2-

5

772 (792, H)

88.4 (90.5)

F

(DPS)TRAP1P

CM000071.1

EAL26542.1

3-

3

644 (688, N)

74.8 (78.1)

F

Anopheles gambiae

       

(AGA)HSP90A1P

XM_308800.2

XP_308800.2

2L-

2

689

78.3

F

(AGA)HSP90A2P

XM_308799.1

XP_308799.1

2L+

3

720

82.1

F

(AGA)HSP90A3PNP

(AGA)HSP90A3N N*

(AGA)HSP90A3PN*

2L+

2

380*

 

P

(AGA)HSP90B1NP

(AGA)HSP90B1N N

(AGA)HSP90B1PN

2R-

2

778 (800, H)

88.9 (91.3)

F

(AGA)TRAP1NP

(AGA)TRAP1N N

(AGA)TRAP1PN

3L+

3

677 (713, H)

76.8 (80.6)

F

Apis mellifera

       

(AME)HSP90A1P

XM_392456.2

XP_392456.2

(Group 7-)

3 (3)

700

80.7

F

(AME)HSP90A2P

XM_395168.2

XP_395168.2

(Group 1-)

3 (3)

699

80.5

F

(AME)HSP90B1P

XM_395614.2

XP_395614.2

(Group 8-)

5 (5)

766 (786, H)

88.5 (90.8)

F

(AME)TRAP1P

XM_623363.1

XP_623366.1

(Group 6-)

13 (13)

668 (693, N)

76.7 (79.6)

F

Caenorhabditis elegans

       

(CEL)HSP90A1

NM_074225.2

NP_506626.1

5+

4 (5)

702

80.2

F

(CEL)HSP90B1

NM_069679.2

NP_502080.1

4+

5 (5)

737 (760, H)

84.6 (87.1)

F

(CEL)TRAP1

NM_171188.2*

NP_741219.1*

3-

9 (9)

464*

 

F

Strongylocentrotus purpuratus

       

(SPU)HSP90A1

XM_777937.1*

XP_783030.1*

N/A-

≥ 8 (9)

510*

 

F

(SPU)HSP90A2

XM_782798.1*

XP_787891.1*

N/A+

≥ 5

319*

 

F

(SPU)HSP90B1

NM_214643.1

NP_999808.1

N/A+

17

784 (806, H)

90.0 (92.3)

F

(SPU)TRAP1

XM_778412.1

XP_783505.1

N/A+

15

665 (691, N)

75.5 (78.6)

F

VERTEBRATE

       

Homo sapiens

       

Chen et al.A (2005)

       

Gallus gallus

       

(GGA)HSP90AA1

X07265.1

CAA30251.1

5-

8

728

84.1

F

(GGA)HSP90AB1

XM_444655.1

XP_444655.1

3-

11

725

83.5

F

(GGA)HSP90B1

NW_060209.1

NP_989620.1

1-

18

774 (795, H)

89.5 (91.6)

F

(GGA)TRAP1

NW_060530.1

XP_414963.1

14-

18

663 (699, N)

75.5 (79.5)

F

Danio rerio

       

(DRE)HSP90AA1

AF068773.1

AAC21567.1

20-

10 (10)

726

83.6

F

(DRE)HSP90AA2NP

(DRE)HSP90AA2NN

(DRE)HSP90AA2PN

20-

10

734

84.7

F

(DRE)HSP90AA3PNP

(DRE)HSP90AA3NN*

(DRE)HSP90AA3PN*

7+

12

838*

 

P

(DRE)HSP90AA4PNP

(DRE)HSP90AA4NN*

(DRE)HSP90AA4PN*

7+

3

417*

 

P

(DRE)HSP90AB1

AF042108.1

AAB96969.1

7-

7 (7)

725

83.4

F

(DRE)HSP90B1

BC063951.1

AAH63951.1

4+

18 (18)

772 (793, H)

88.9 (91.3)

F

(DRE)HSP90B2NP

(DRE)HSP90B2NN

(DRE)HSP90B2PN

4+

18

773 (794, H)

89.1 (91.4)

F

(DRE)TRAP1NP

(DRE)TRAP1N*

(DRE)TRAP1N*

23+

≥8

414*

 

F

Ciona intestinalis

       

(CIN)HSP90A1

AK115284.1

AK115284.1PN

(Sca 118+)

11 (12)

726

83.3

F

(CIN)HSP90B1NP

(CIN)HSP90B1NN*

(CIN)HSP90B1PN*

(Sca 963-)

≥15

732*

 

F

(CIN)HSP90B2PNP

(CIN)HSP90B2NN*

(CIN)HSP90B2PN*

(Sca 462-)

≥2

119*

 

P

(CIN)TRAP1NP

(CIN)TRAP1N

(CIN)TRAP1N

(Sca 143+)

13

687 (719, N)

77.9 (81.5)

F

  1. a P predicted by genome annotation; NP predicted in this study. The abbreviations of species names in parenthesis are in Table 3. The genes with their nomenclatures ended with "P" are putative pseudogenes.
  2. bN new sequences identified/deduced in this study and available at Additional File 1. The sequences marked with "*" are not full-length.
  3. c Chromosomal location. + forward strand; – reverse strand. The numbers/letters are the chromosome numbers/letters, and N/A indicates unavailability of the chromosome number and Sca indicates Scaffold.
  4. d Total number of exons in coding regions. The numbers in parenthesis include exons in untranslated regions.
  5. e length of mature polypeptide with that of precursor and prediction method (Hidden Markov models, H; Neural networks, N) in parenthesis. The sequences marked "*" are incomplete, or from putative pseudogenes, and their mature polypeptides are not predicted.
  6. f molecular mass of mature polypeptide with that of precursor in parenthesis.
  7. g F – functional genes predicted by transcript and domain identification. P – putative pseudogenes.
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