From: Differences in the evolutionary history of disease genes affected by dominant or recessive mutations
CS mouse | ||||
---|---|---|---|---|
nD | Disease | Disease dominant | Disease recessive | |
Enzyme regulation | 0.778 | 0.790 | 0.818 | 0.755 |
Transcription regulation | 0.800 | 0.860 | 0.871 | 0.824 |
Nucleic acid binding | 0.795 | 0.835 | 0.851 | 0.803 |
Catalysis | 0.809 | 0.819 | 0.832 | 0.815 |
Signal transduction | 0.751 | 0.748 | 0.776 | 0.708 |
Structural molecule | 0.828 | 0.831 | 0.838 | 0.815 |
Transporter | 0.824 | 0.848 | 0.862 | 0.841 |
Carrier | 0.838 | 0.881 | 0.884 | 0.880 |
CS paralogues | ||||
nD | Disease | Disease dominant | Disease recessive | |
Enzyme regulation | 0.374 | 0.272 | 0.300 | 0.236 |
Transcription regulation | 0.353 | 0.422 | 0.440 | 0.359 |
Nucleic acid binding | 0.358 | 0.370 | 0.431 | 0.250 |
Catalysis | 0.381 | 0.355 | 0.430 | 0.331 |
Signal transduction | 0.383 | 0.347 | 0.406 | 0.261 |
Structural molecule | 0.449 | 0.482 | 0.595 | 0.207 |
Transporter | 0.424 | 0.400 | 0.539 | 0.331 |
Carrier | 0.425 | 0.432 | 0.571 | 0.402 |
K A /K S chimpazee | ||||
nD | Disease | Disease dominant | Disease recessive | |
Enzyme regulation | 0.163 | 0.233 | 0.223 | 0.251 |
Transcription regulation | 0.170 | 0.144 | 0.109 | 0.253 |
Nucleic acid binding | 0.188 | 0.164 | 0.149 | 0.190 |
Catalysis | 0.185 | 0.179 | 0.150 | 0.189 |
Signal transduction | 0.213 | 0.173 | 0.138 | 0.238 |
Structural molecule | 0.201 | 0.183 | 0.155 | 0.250 |
Transporter | 0.176 | 0.166 | 0.082 | 0.213 |
Carrier | 0.170 | 0.197 | 0.123 | 0.213 |