Item | Name | Acce # | Gene Description | Evidence for Down Regulation |
---|---|---|---|---|
1 | CLU | NM_001831 | clusterin | literature, [30,34] |
2 | GFAP | NM_002055 | glial fibrillary acidic protein | literature, [29] |
3 | CP | NM_000096 | ceruloplasmin | literature, [53] |
4 | DYRK1A | NM_001396 | dual-specificity tyrosine-(Y) phosphorylationregulated kinase 1A | literature, [74] |
5 | FKBP1A | NM_000801 | FK506 binding protein 1A | literature, [57] |
6 | FTL | BC058820 | ferritin, light polypeptide | literature [3,34,52] |
7 | M6PR | NM_002355 | mannose-6-phosphate receptor | literature, [75] |
8 | MAP2 | NM_031846 | microtubule-associated protein 2 | literature, [3] |
9 | MBP | BC008749 | myelin basic protein | literature, [49] |
10 | MT1F | NM_005949 | metallothionein 1F | literature, [31] |
11 | RPL23 | BC010114 | ribosomal protein L23 | literature, [3] |
12 | RPS27 | NM_001030 | ribosomal protein S27 | literature, [76] |
13 | VDAC2 | NM_003375 | voltage-dependent anion channel 2 | literature, [77] |
14 | YWHAE | BC001440 | tyrosine 3-monooxygenase/tryptophan-5-monooxygenase activation protein, epsilon polypeptide | literature, [78] |
15 | AGT | NM_000029 | angiotensinogen | literature, [34,79] |
16 | STXBP1 | NM_003165 | syntaxin binding protein 1 | literature, [3,32], qRT-PCR did not show significant change |
17 | KNS2 | BC008881 | kinesin 2 60/70kDa | inferred, up regulated in injured optic nerve, [33], qRT-PCR did not show significant change |
18 | C21orf33 | NM_004649 | chromosome 21 open reading frame 33 | inferred, elevated in fetal Down syndrome brain, [80] |
19 | FKBP2 | NM_057092 | FK506 binding protein 2 | inferred, [57] |
20 | FREQ | NM_014286 | frequenin homolog | inferred, up in Schizophrenia, [81] |
21 | GRM3 | NM_000840 | glutamate receptor, metabotropic 3 | inferred, GRM2 and 4 increased in ischemic neurodegeneration, [82] |
22 | NPTX1 | NM_002522 | neuronal pentraxin I | inferred, short pentraxins are upregulated in AD, [50] |
23 | PDE8A | NM_002605 | phosphodiesterase 8A | inferred, family member of PDE8B, is upregulated in AD, [83] |
24 | AHCTF1 | AB059277 | AT hook containing transcription factor 1 | qRT-PCR |
25 | APRIN | NM_015032 | androgen-induced proliferation inhibitor | qRT-PCR |
26 | CENTG2 | NM_014914 | centaurin, gamma 2 | qRT-PCR |
27 | LMNA | NM_170708 | lamin A/C | qRT-PCR |
28 | PLRG1 | BC020786 | pleiotropic regulator 1 | qRT-PCR |
29 | PREPL | AB007896 | prolyl endopeptidase-like | qRT-PCR |
30 | RPS20 | NM_001023 | ribosomal protein S20 | qRT-PCR |
31 | SAFB | NM_002967 | scaffold attachment factor B | qRT-PCR |
32 | SPTBN2 | NM_006946 | spectrin, beta, non-erythrocytic 2 | qRT-PCR |
33 | SRGAP2 | XM_059095 | SLIT-ROBO Rho GTPase activating protein 2 | qRT-PCR |
34 | USP10 | NM_005153 | ubiquitin specific protease 10 | qRT-PCR |
35 | ARHGAP1 | NM_004308 | Rho GTPase activating protein 1 (CDC42GAP) | qRT-PCR, inferred, CDC42 is upregulated in AD, [60] |
36 | DRD1IP | NM_015722 | dopamine receptor D1 interacting protein | qRT-PCR, inferred, up regulated in schizophrenia, [84] |
37 | MARK2 | BC008771 | MAP/microtubule affinity-regulating kinase 2 | qRT-PCR, inferred, [85] |
38 | SCARB2 | NM_005506 | scavenger receptor class B, member 2, CD36 antigen | qRT-PCR, Inferred, inflammation increases CD36 mRNA, thus induceCD36 antigen, [51] |
39 | SEPT6 | NM_015129 | septin 6 | qRT-PCR, inferred, increased in motor deficient mice,[86] |
40 | SKP1A | NM_170679 | S-phase kinase-associated protein 1A | qRT-PCR, inferred, overexpression of SKP1A together with APP increase the production of Aβ, [87] |