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Table 3 Genomic features significantly different in islands compared with whole genomic DNA.

From: Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts

   

Islands that overlap with replication timing markers1

Feature

Genome

All Islands

Islands with a ≥ 1.65-timing ratio1

Islands with a ≥ 1.75-timing ratio1

Islands with a ≥ 1.85-timing ratio1

100-kb windows

28358

1749

228

144

78

Genes

30078

2815

606

428

252

Genes/100 kb

1.06

1.60

2.66

2.97

3.23

Promoters 2

10415

948

223

170

111

Promoters/100 kb

0.37

0.55

0.98

1.18

1.42

Transcribed

37.61%

43.73%

56.37%

55.88%

54.79%

Translated

1.11%

1.81%

3.08%

3.42%

3.35%

CpG_Islands

1.94%

4.05%

5.20%

5.83%

6.58%

CpG_Content

1.96%

2.76%

3.39%

3.63%

3.86%

GC_Content

40.88%

45.51%

48.71%

49.82%

50.52%

Conserved

4.83%

5.78%

7.18%

7.50%

7.86%

All_Repeats

48.52%

45.68%

44.23%

44.78%

46.21%

SINE

13.67%

17.18%

23.28%

25.05%

27.71%

   Alu

10.75%

13.54%

18.99%

20.66%

23.59%

   MIR

2.92%

3.64%

4.29%

4.39%

4.11%

LINE

21.10%

15.94%

11.55%

10.73%

10.06%

   L1

17.48%

12.27%

7.83%

6.97%

6.53%

LTR

8.71%

7.45%

5.28%

4.98%

4.65%

   MaLR

3.79%

3.30%

2.37%

2.34%

2.18%

   ERV1

3.00%

2.58%

1.76%

1.66%

1.51%

   ERVL

1.61%

1.32%

0.85%

0.75%

0.71%

DNA transposons

3.02%

2.71%

2.35%

2.23%

2.02%

   MER2_type

1.06%

0.79%

0.63%

0.55%

0.54%

   Mariner

0.10%

0.07%

0.04%

0.04%

0.03%

Low_complexity

0.58%

0.54%

0.51%

0.50%

0.49%

Tandem_Repeats

1.82%

2.64%

2.1%

2.24%

2.44%

  1. 1- Replication timing ratio determined by Woodfine et al. [19].
  2. 2- Active promoters in IMR90 fibroblasts as determined by Kim et al. [44].