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Table 2 Examples of TCDD-elicited gene expression responses unique to Hepa1c1c7 cells

From: In vivo – in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue

Accession

Gene name

Gene Symbol

Entrez Gene ID

Fold changea

Time pointsb (hrs)

AA111722

cyclin D1

Ccnd1

12443

-1.7

4, 8, 12, 24c, 48

AA914666

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Cdkn2b

12579

2.4

4c, 8, 48

BC008247

cyclin B2

Ccnb2

12442

-1.8

24c

BG064846

cell division cycle 2 homolog A (S. pombe)

Cdc2a

12534

-1.5

12, 24c

AA011839

minichromosome maintenance deficient 2 mitotin (S. cerevisiae)

Mcm2

17216

-1.8

8c, 12

BG074721

minichromosome maintenance deficient 7 (S. cerevisiae)

Mcm7

17220

-1.7

8, 12c, 24

AA003042

myeloblastosis oncogene-like 2

Mybl2

17865

-2.2

8c, 12, 24

L27122

UDP glucuronosyltransferase 1 family, polypeptide A2

Ugt1a2

22236

2.8

4, 8, 12c, 24, 48

  1. aMaximum absolute fold change determined by microarray analysis
  2. bDifferentially regulated genes with P1(t) > 0.9999 and |fold change| > 1.5
  3. cTime point representing the maximum |fold change|