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Table 3 30 Epithelial-specific genes as identified by the TPE analysis.

From: A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes

 

SAGE Tag count#

   

SAGE Tag Sequence

PBEC CTRL

PBEC IL1β/TNFα

KC CTRL

KC TNFα

Symbol

Description

Barrier formation

AAAGCACAAG

267

252

136

235

KRT6A

keratin 6A

yes

CTTCCTTGCC

181

216

431

380

KRT17

keratin 17

yes

GCCCCTGCTG

96

180

108

115

KRT5

keratin 5

yes

TAAACCTGCT

40

68

758

439

LGALS7

lectin, galactoside-binding, soluble, 7 (galectin 7)

 

TTGAATCCCC

30

80

56

50

PI3

protease inhibitor 3, skin-derived (SKALP), Elafin

yes

CCCTTGAGGA

27

56

264

176

SPRR1B

small proline-rich protein 1B (cornifin)

yes

CGAATGTCCT

21

60

84

97

KRT6B

keratin 6B

yes

CAGCTGTCCC

21

25

26

29

KRT16

keratin 16

yes

AGCTTCTACC

17

22

14

25

HCG9

HLA complex group 9

 

CATTGTAAAT

16

12

26

14

SERPINB5

serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5

 

GATGTGCACG

12

26

419

514

KRT14

keratin 14

yes

CTGTCACCCT

9

25

126

75

SPRR1A

Small proline-rich protein 1A

yes

CCCTGTTGAT

8

8

7

18

KLK7

kallikrein 7 (chymotryptic, stratum corneum)

 

GGCTTCTAAC

4

16

35

38

SPRR2B

small proline-rich protein 2B

yes

GAAGCACAAG

4

13

9

18

 

Transcribed sequences

 

CCAGCGCCAA

3

16

16

14

C4.4A

GPI-anchored metastasis-associated protein homolog

 

GCTTCCTCGG

2

11

2

5

RHCG

Rhesus blood group, C glycoprotein

 

TCTCTTGGGG

2

4

0

2

FLJ11036

hypothetical protein FLJ11036

 

AAAGCACAAT

1

1

0

5

TRA1

tumor rejection antigen (gp96) 1

 

TCCTGGATCA

1

1

0

2

KLK10

kallikrein 10

 

ATCCCTTGCT

1

2

9

2

 

Transcribed sequences

 

AGAGCACAAG

1

1

2

5

 

Transcribed sequences

 

CTTGCCTTGC

0

2

0

2

ZDHHC9

zinc finger, DHHC domain containing 9

 

ACCTCCACTG

0

2

54

34

UNQ467

KIPV467

 

CTGCTCAATG

0

3

9

11

TGM1

transglutaminase 1

yes

TTCCCTTACC

0

2

5

16

SPRL6A

small proline rich-like 6A

yes

ACCTGGAGGG

0

12

28

23

PCBP1

poly(rC) binding protein 1

 

GGGCCACGGC

0

1

7

14

MMP11

matrix metalloproteinase 11 (stromelysin 3)

 

ACTAGCACAG

0

7

0

2

IL1F9

interleukin 1 family, member 9

 

TAGACCTGCT

0

3

2

2

 

CDNA FLJ32217 fis, clone PLACE6003771

 
  1. Putative epithelial-specific tags as presented in pane iv of the scatter plot in figure 1 as identified by the TPE analysis are listed in table 3. From left to right are indicated the SAGE tag sequence, the normalized SAGE tag counts (unstimulated PBEC, IL1β/TNFα-stimulated PBEC, unstimulated KC and TNFα-stimulated KC), HUGO approved gene symbol and gene description and the putative involvement in epithelial barrier formation. Underlined tag counts indicate statistical significant difference in expression in the original SAGE data sets of PBEC (unstimulated vs. IL1β/TNFα) or KC (unstimulated vs. TNFα). # A selection of these SAGE tag counts were represented in previously published tables [11,12]; all tag counts are available online through the NCBI Gene Expression Omnibus website [37] with GEO accessions as listed in the methods.
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BMC Genomics

ISSN: 1471-2164

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