Figure 4

Genomic context of BTC1_113FL. Top panel (A). A modified image from the UCSC cow genome browser (March 2005, Btau_2.0) showing BTC1_113FL aligned to the cow genome (Contig74653; GenBank accession no. AAFC02073929). A track for cattle ESTs ("squish mode") shows high support for alternatively spliced cattle transcripts encoded in this region and the presence of 3' exons of SECP43. Genscan predicts a gene within the alignment of BTC1_113FL but does not predict all of the exons from ESTs. A CpG island is located at the 5' end of the predicted gene. Bottom panel (B). Anchoring of BTC1_113FL represented as a block arrow, to HSA1p35.3 (May 2004, Hg17). BTC1_113FL, was anchored on the basis of its complete alignment to cattle contig74653 and similarity of flanking sequence in the contig to the human genome (shown as vertical lines along the track). This region is syntenic to a segment of BTA2 (shown as a separate track), consistent with RH mapping data [23]. UCSC Genome Browser tracks for known human proteins, Genscan genes, sno/miRNA, conserved sequences, and segmental duplication are unmodified.