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Table 4 Reports of positive selection pressure on CT genes

From: Rapid evolution of cancer/testis genes on the X chromosome

CT_family

Gene name

Human RefSeq

Reference

Present work#

CT1

MAGEA4

NM_002362

I

Yes

CT1

MAGEA5

NM_021049

I

Yes

CT1

MAGEA10

NM_021048

I

Yes

CT2

BAGE2

NM_182482

I

 

CT3

MAGEB2

NM_002364

I

Yes

CT3

MAGEB3

NM_002365

I

Yes

CT5

SSX1

NM_005635

I, III

Yes

CT5

SSX8

NM_174961

I, III

Yes

CT7

MAGEC2

NM_016249

I

 

CT7

MAGEC3

NM_138702

I

 

CT11

SPANX-N2

NM_001009615

III

 

CT11

SPANX-N3

NM_001009609

III

 

CT11

SPANX-N4

NM_001009613

III

 

CT11

SPANX-N5

NM_001009616

III

 

CT11

SPANXA

NM_013453

III

 

CT11

SPANXB

NM_032461

III

 

CT11

SPANXC

NM_022661

III

 

CT14

SAGE1

NM_018666

I, II

Yes

CT16

PAGE1

NM_003785

I

Yes

CT37

FMR1NB

NM_152578

I

Yes

CT38

FTHL17

NM_031894

I

Yes

CT48

SLCO6A1

NM_173488

I

 

CT55

CXorf48

NM_017863

I

 

CT56

THEG

NM_016585

I

Yes

CT63

PASD1

NM_173493

I

 

CT65

TULP2

NM_003323

I

Yes

CT77

CPXCR1

NM_033048

I

Yes

CT80

PIWIL2

NM_018068

I

 

CTNA

PRAME

NM_006115

I

Yes

CTNA

PRAME

cluster on chromosome 1

IV

Yes

  1. Positive selection pressure on CT genes, from analysis of human and chimpanzee sequences, reported in: I, as defined by dN/dS > 1 [18, 33]. II, as defined by likelihood ratio test with p-value < 0.05 [35]. III, as defined by dN/dS > 1 [27] IV, inferred from dN/dS > 1 and sites modelling on human alignments [28] # Confirmed 16 previously reported positively selected CT genes, plus an additional 18 positively selected CT genes (see Table 2).
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