Figure 4

Association of SNPs in the 100-kb region of DEFA1A3 cluster with the absence of the DEFA3 gene. A. Diagram with the association results testing each SNP with DEFA3 absence under a recessive mode of inheritance. The red line indicates significance after Bonferroni correction. Positive association was only detected in Caucasian population. B. Haplotype blocks defined by the haploview program in the Caucasian population. The estimated frequency of each haplotype is depicted on its right hand side. The boxes represent the haplotype found associated to DEFA3 absence and the corresponding p-value is shown.