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Table 2 Functional classification and ratios of genes down-regulated (< 1.5 fold) by exposure to cobalt across all time points

From: Global gene expression profiling in human lung cells exposed to cobalt

Gene ID

Gene Name

Time (h)

Microarray Ratio a

qRT-PCR Ratio b

Development, differentiation and proliferation

NDRG4

NDRG family member 4

24

0.58

0.29 ***

SEZ6L

seizure related 6 homolog (mouse)-like

4

0.62

 

Signal transduction and trafficking

ATP6V1A

ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A

2

0.66

 

AXL

AXL receptor tyrosine kinase

4

0.60

1.36 ***

GFRA2

GDNF family receptor alpha 2

0.5

0.63

0.09 *

ICAM1

intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

2

0.60

 

IFNAR2

interferon (alpha, beta and omega) receptor 2

24

0.61

0.55 ***

MAPK10

mitogen-activated protein kinase 10

24

0.47

0.31 ***

S 100A 4

S100 calcium binding protein A4

2

0.64

 

TFRC

transferrin receptor (p90, CD71)

0.5

0.50

0.65 *

Cell defense

BAG1

BCL2-associated athanogene

2

0.65

0.55 **

TNFSF6

tumor necrosis factor (ligand) superfamily, member 6

4

0.54

 

Protein expression and turn-over

CNDP2

CNDP dipeptidase 2 (metallopeptidase M20 family)

4

0.57

 

FBXL2

F-box and leucine-rich repeat protein 2

0.5

0.55

0.75 ****

TIMP2

tissue inhibitor of metalloproteinase 2

24

0.63

0.54 ***

Gene transcription and modification

MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

2

0.28

0.59 **

NT5E

5'-nucleotidase, ecto (CD73)

24

0.50

 

PAI-RBP1

PAI-1 mRNA-binding protein

2

0.62

 

SFRS1

splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)

0.5

0.52

 

SIN3A

SIN3 homolog A, transcriptional regulator (yeast)

24

0.63

2.21 *

Cell structure and mobility

FAT2

FAT tumor suppressor homolog 2 (Drosophila)

4

0.56

 

TUBB2

tubulin, beta, 2

4

0.62

 

VIL2

villin 2 (ezrin)

0.5

0.64

 

Metabolism and energy

AKR1C3

aldo-keto reductase family 1, member C3

24

0.53

 

ALDH1A1

aldehyde dehydrogenase 1 family, member A1

24

0.60

 

GLCE

glucuronyl C5-epimerase

0.5

0.46

 

GPD2

glycerol-3-phosphate dehydrogenase 2 (mitochondrial)

4

0.55

 

MTHFS

5,10-methenyltetrahydrofolate synthetase

2

0.52

 

Unknown function

C20orf30

chromosome 20 open reading frame 30

2

0.48

 

C20orf30

chromosome 20 open reading frame 30

24

0.60

 

FLJ12806

hypothetical protein FLJ12806

0.5

0.64

 

KIAA1582

KIAA1582 protein

24

0.58

 
  1. a: p value < 0.05 with 1.5 fold change.
  2. b: validation with quantitative qRT-PCR (lines in bold) :
  3. *: p value < 0.005, ** p value < 0.01, *** p value < 0.05, **** p value < 0.1.
  4. Microarray p-values were calculated using a t-test statistical analysis (Benjamini-Hochberg FDR) on Genespring software. Pair Wise Fixed Reallocation Randomized Test was used to calculate qRT-PCR p values with REST software.
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BMC Genomics

ISSN: 1471-2164

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