Table 3 Results of an enrichment analysis on 145 genes that show significant differences in expression between the four different species of Apis

GO:0009607

response to biotic stimulus

4

93

0.0513

20

0.1869

1.15E-07

Tctp, Hsp70Aa, e, CG7966, Hsc70Cb, CG32687, Hop, Tsp96F, Hsp83, CG10178, CG5001, Ugt86Dd, Hsc70-4, PGRP-SC2, Gp93, dsd, Tsf1, PebIII, 18w, l(2)efl

GO:0006952

defense response

5

89

0.0491

19

0.1776

2.79E-07

Tctp, Hsp70Aa, e, CG7966, Hsc70Cb, CG32687, Hop, Tsp96F, Hsp83, CG10178, CG5001, Ugt86Dd, Hsc70-4, PGRP-SC2, Gp93, dsd, Tsf1, 18w, l(2)efl

GO:0009408

response to heat

6, 5

12

0.0066

5

0.0467

0.0003452

Hsp70Aa, Hsp83, CG5001, Hsc70-4, l(2)efl

GO:0006457

protein folding

7

45

0.0248

9

0.0841

0.0007291

Hsp70Aa, Hsc70Cb, Hop, Hsp83, FKBP59, CG5001, Hsc70-4, Gp93, l(2)efl

GO:0006950

response to stress

4

65

0.0359

11

0.1028

0.0008152

Hsp70Aa, Hsc70Cb, Hop, Tsp96F, Hsp83, CG5001, Hsc70-4, Gp93, PebIII, 18w, l(2)efl

GO:0042417

dopamine metabolism

9, 8, 6

2

0.0011

2

0.0187

0.0034525

e, Dat

GO:0043473

pigmentation

2

8

0.0044

3

0.028

0.0083358

e, b, Dat

GO:0048066

pigmentation during development

3

8

0.0044

3

0.028

0.0083358

e, b, Dat

GO:0005975

carbohydrate metabolism

5

113

0.0623

12

0.1121

0.0172185

Pglym78, CG6439, CG10178, Mdh, l(2)01810, Sulf1, Ugt86Dd, CG1271, PGRP-SC2, Sodh-2, CG14621, α-Man-IIb

GO:0042752

regulation of circadian rhythm

4, 5

4

0.0022

2

0.0187

0.0183819

Hsp83, Dat

GO:0046916

transition metal ion homeostasis

8

4

0.0022

2

0.0187

0.0183819

Tsf1, CG4349

GO:0006584

catecholamine metabolism

7, 8

4

0.0022

2

0.0187

0.0183819

e, Dat

GO:0006519

amino acid and derivative metabolism

5

67

0.037

8

0.0748

0.0252803

e, CG1732, b, CG6028, CG6439, Eaat2, CG8745, Dat

GO:0009628

response to abiotic stimulus

4

80

0.0441

9

0.0841

0.0254136

Hsp70Aa, wun, Rh6, Hsp83, CG10178, CG5001, Ugt86Dd, Hsc70-4, l(2)efl

GO:0007530

sex determination

3

12

0.0066

3

0.028

0.0258228

fru, gro, CG3726

GO:0009613

response to pest, pathogen or parasite

6, 5

12

0.0066

3

0.028

0.0258228

Tsp96F, PebIII, 18w

GO:0018958

phenol metabolism

6

5

0.0028

2

0.0187

0.0288583

e, Dat

GO:0006807

nitrogen compound metabolism

4

83

0.0458

9

0.0841

0.0302461

e, CG1732, b, CG6028, CG6439, pyd3, Eaat2, CG8745, Dat

GO:0016614

oxidoreductase activity, acting on CH-OH group of donors

4

35

0.0197

7

0.066

0.0029256

CG6439, CG10638, Mdh, CG9360, Sodh-2, antdh, CG10962

GO:0008171

O-methyltransferase activity

6

2

0.0011

2

0.0189

0.0035187

CG10527, Pcmt

GO:0005386

carrier activity

3

131

0.0736

15

0.1415

0.0052529

CG32250, CG31547, CG1732, Cralbp, CG9317, Eaat2, l(3)neo18, Tsp5D, CG33310, l(2)01810, CG1271, Psa, Tsf1, PebIII, CG14621

GO:0051082

unfolded protein binding

4

22

0.0124

5

0.0472

0.0066411

Hop, Hsp83, CG5001, Hsc70-4, Gp93

GO:0004263

chymotrypsin activity

7

3

0.0017

2

0.0189

0.0099384

CG32130, CG4998

GO:0015020

Glucuronosyltransferase activity

6

3

0.0017

2

0.0189

0.0099384

CG10178, Ugt86Dd

GO:0008238

exopeptidase activity

5

17

0.0096

4

0.0377

0.0131342

east, CG4678, Ance, Psa

GO:0015290

electrochemical potential-driven transporter activity

4

48

0.027

7

0.066

0.0149443

CG31547, CG1732, CG9317, Eaat2, l(2)01810, Psa, CG14621

GO:0015291

porter activity

5

48

0.027

7

0.066

0.0149443

CG31547, CG1732, CG9317, Eaat2, l(2)01810, Psa, CG14621

GO:0015293

symporter activity

6

18

0.0101

4

0.0377

0.0159093

CG31547, CG1732, Eaat2, l(2)01810

GO:0016831

carboxy-lyase activity

5

10

0.0056

3

0.0283

0.0162543

b, CG6028, Mdh

GO:0008237

metallopeptidase activity

5

38

0.0214

6

0.0566

0.0165483

Nep2, east, CG4678, Ance, Psa, S2P

GO:0008199

ferric iron binding

7

4

0.0022

2

0.0189

0.0187129

Tsf1, CG4349

GO:0016810

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

4

19

0.0107

4

0.0377

0.0189845

pyd3, Sirt2, gro, PGRP-SC2

GO:0008509

anion transporter activity

4

31

0.0174

5

0.0472

0.0251189

CG31547, Eaat2, Atet, l(2)01810, CG14621

GO:0015296

anion:cation symporter activity

7, 5

12

0.0067

3

0.0283

0.0264295

CG31547, Eaat2, l(2)01810

GO:0015370

solute:sodium symporter activity

8, 6

12

0.0067

3

0.0283

0.0264295

CG1732, Eaat2, l(2)01810

GO:0019842

vitamin binding

3

5

0.0028

2

0.0189

0.0293608

Cralbp, CG8745

GO:0005283

sodium:amino acid symporter activity

7, 8, 9, 10, 5

5

0.0028

2

0.0189

0.0293608

CG1732, Eaat2

GO:0004295

trypsin activity

7

5

0.0028

2

0.0189

0.0293608

CG32130, CG4998

GO:0016830

carbon-carbon lyase activity

4

13

0.0073

3

0.0283

0.0323556

b, CG6028, Mdh

GO:0008235

metalloexopeptidase activity

6

13

0.0073

3

0.0283

0.0323556

east, CG4678, Psa

GO:0005279

amino acid-polyamine transporter activity

5, 6

14

0.0079

3

0.0283

0.0387781

CG31547, CG1732, Eaat2