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Table 2 Enriched cluster categories in region A: "Pezizomycotina abundant"

From: Comparison of protein coding gene contents of the fungal phyla Pezizomycotina and Saccharomycotina

Software or database

Database identifier

Category

Count of clusters in region

% of clusters in region

% of all clusters with category

P-value

Author assignment

Figure 13

ProtFun

-

Enzyme/nonenzyme: Enzyme

180

91.0

5

1.60E-11

-

-

ProtFun

-

Enzyme class: Uncategorised

147

74.0

6

1.60E-17

-

-

ProtFun

-

Cellular role: Uncategorised

143

72.0

4

2.10E-02

-

-

Funcat

01

Metabolism

81

41.0

6

8.00E-06

Metabolism

-

ProtFun

-

TargetP: Uncategorised

71

36.0

5

1.40E-04

-

-

Funcat

01.05

C-compound and carbohydrate metabolism

41

21.0

10

1.30E-07

Plant biomass degradation

-

ProtFun

-

TargetP: Secretion

39

20.0

9

1.30E-07

-

-

ProtFun

-

Cellular role: Cell envelope

30

15.0

11

1.20E-08

-

-

Funcat

01.05.01

C-compound and carbohydrate utilization

29

15.0

10

1.30E-05

Plant biomass degradation

-

Funcat

32

Cell rescue, defence and virulence

24

12.0

7

6.50E-03

Virulence/Defence

-

Funcat

01.05.01.01

C-compound, carbohydrate catabolism

22

11.0

22

4.40E-11

Plant biomass degradation

-

ProtFun

-

TMHMM: Uncategorised

20

10.0

7

3.70E-03

-

-

Funcat

01.20

Secondary metabolism

19

10.0

22

1.40E-09

2ary metabolism

-

Funcat

32.05

Disease, virulence and defence

14

7.0

23

1.00E-07

Virulence/Defence

-

Funcat

01.05.01.01.02

Polysaccharide degradation

13

7.0

27

3.50E-08

Plant biomass degradation

-

Funcat

32.05.05

Virulence, disease factors

9

5.0

45

3.20E-08

Virulence/Defence

-

Interpro

IPR001128

Cytochrome P450

8

4.0

42

1.30E-07

2ary metabolism

YES

Interpro

IPR002347

Glucose/ribitol dehydrogenase

8

4.0

21

4.60E-05

2ary metabolism

YES

Funcat

32.07

Detoxification

7

4.0

10

2.20E-02

2ary metabolism

-

Interpro

IPR002198

Short-chain dehydrogenase/reductase SDR

7

3.5

21

1.60E-04

2ary metabolism

YES

Interpro

IPR006094

FAD linked oxidase, N-terminal

5

2.5

56

6.30E-06

2ary metabolism

YES

Interpro

IPR003042

Aromatic-ring hydroxylase

5

2.5

36

8.60E-05

2ary metabolism

YES

Funcat

01.25

Extracellular metabolism

4

2.0

36

7.30E-04

Plant biomass degradation

-

Funcat

02.16

Fermentation

4

2.0

20

8.00E-03

Metabolism

-

Funcat

01.05.01.01.01

Sugar, glucoside, polyol and carboxylate catabolism

4

2.0

19

9.50E-03

Plant biomass degradation

-

Funcat

30.05

Transmembrane signal transduction

4

2.0

12

4.50E-02

Signalling

-

Interpro

IPR011050

Pectin lyase fold/virulence factor

4

2.0

27

1.60E-03

Plant biomass degradation

NO

Interpro

IPR000873

AMP-dependent synthetase and ligase

4

2.0

25

2.10E-03

2ary metabolism

YES

Interpro

IPR008985

Concanavalin A-like lectin/glucanase

4

2.0

24

2.60E-03

Plant biomass degradation

NO

Funcat

32.10.07

Degradation of foreign (exogenous) polysaccharides

3

2.0

50

1.20E-03

Plant biomass degradation

-

Funcat

01.01.09.05

Metabolism of tyrosine

3

2.0

43

2.10E-03

2ary metabolism

-

Funcat

01.05.01.01.09

Aerobic aromate catabolism

3

2.0

43

2.10E-03

Metabolism

-

Funcat

32.10

Degradation of foreign (exogenous) compounds

3

2.0

38

3.30E-03

Plant biomass degradation

-

Funcat

02.25

Oxidation of fatty acids

3

2.0

27

8.80E-03

2ary metabolism

-

Interpro

IPR010730

Heterokaryon incompatibility

3

1.5

75

1.80E-04

Mating

YES

Interpro

IPR003661

Histidine kinase A, N-terminal

3

1.5

43

1.40E-03

Signalling

NO

Interpro

IPR006163

Phosphopantetheine-binding

3

1.5

43

1.40E-03

2ary metabolism

YES

Interpro

IPR005467

Histidine kinase

3

1.5

38

2.20E-03

Signalling

NO

Interpro

IPR001789

Response regulator receiver

3

1.5

33

3.20E-03

Signalling

NO

Funcat

30.05.01.10

Two-component signal transduction system

2

1.0

67

4.90E-03

Signalling

-

Funcat

32.05.05.01

Toxins

2

1.0

50

9.50E-03

2ary metabolism

-

Funcat

01.01.09.05.02

Degradation of tyrosine

2

1.0

40

1.50E-02

2ary metabolism

-

Funcat

01.20.37

Biosynthesis of peptide derived compounds

2

1.0

40

1.50E-02

2ary metabolism

-

Funcat

34.11.11

Rhythm (e.g. circadian, ultradian)

2

1.0

40

1.50E-02

Other

-

Funcat

01.01.09.04

Metabolism of phenylalanine

2

1.0

33

2.30E-02

2ary metabolism

-

Funcat

01.25.01

Extracellular polysaccharide degradation

2

1.0

33

2.30E-02

Plant biomass degradation

-

Funcat

16.05

Polysaccharide binding

2

1.0

33

2.30E-02

Plant biomass degradation

-

Funcat

16.21.05

FAD/FMN binding

2

1.0

33

2.30E-02

2ary metabolism

-

Funcat

01.01.11.03.02

Degradation of valine

2

1.0

29

3.10E-02

2ary metabolism

-

Funcat

30.05.01

Receptor enzyme mediated signalling

2

1.0

25

4.00E-02

Signalling

-

Funcat

01.20.35.01

Biosynthesis of phenylpropanoids

2

1.0

22

5.00E-02

2ary metabolism

-

Interpro

IPR000675

Cutinase

2

1.0

100

1.30E-03

Plant biomass degradation

NO

Interpro

IPR001077

O-methyltransferase, family 2

2

1.0

100

1.30E-03

Regulation

NO

Interpro

IPR002227

Tyrosinase

2

1.0

100

1.30E-03

2ary metabolism

NO

Interpro

IPR008922

Di-copper centre-containing

2

1.0

100

1.30E-03

Dubious

NO

Interpro

IPR012951

Berberine/berberine-like

2

1.0

100

1.30E-03

2ary metabolism

NO

Interpro

IPR000743

Glycoside hydrolase, family 28

2

1.0

67

3.70E-03

Plant biomass degradation

NO

Funcat

01.05.01.01.11

Anaerobic aromate catabolism

1

1.0

100

4.10E-02

Metabolism

-

Funcat

01.20.01.09

Biosynthesis of aminoglycoside antibiotics

1

1.0

100

4.10E-02

2ary metabolism

-

Funcat

01.20.23

Biosynthesis of secondary products derived from L-methionine

1

1.0

100

4.10E-02

2ary metabolism

-

Funcat

01.20.36

Non-ribosomal peptide synthesis

1

1.0

100

4.10E-02

2ary metabolism

-

Funcat

01.20.37.05

Biosynthesis of beta-lactams

1

1.0

100

4.10E-02

2ary metabolism

-

Funcat

02.16.03.03

Heterofermentative pathway and fermentation of other saccharides

1

1.0

100

4.10E-02

Metabolism

-

Funcat

32.05.05.03

Bacteriocins

1

1.0

100

4.10E-02

2ary metabolism

-

Funcat

32.07.09

Detoxification by degradation

1

1.0

100

4.10E-02

2ary metabolism

-

Funcat

34.11.01.01

Light environment response

1

1.0

100

4.10E-02

Signalling

-

Funcat

36.20.18

Plant hormonal regulation

1

1.0

100

4.10E-02

Signalling

-

  1. Software or database that the categories were derived from, category database identifier, category name, count of clusters with the category, percentage of all clusters in this region, percentage of all clusters with the category and significance of enrichment are shown for categories which are enriched in the region (Figure 4) with a p < 0.01. Column "Author assignment" shows an assignment to general themes, based on the respective database, that summarise the InterPro and Funcat categories. While the other assignments are directly based on the databases, "Secondary metabolism" covers entries which are known to participate also in secondary metabolism ([61, 62], Funcat and InterPro). For InterPro entries whether the entry is found from Figure 9 is specified in column "Figure 9". InterPro entries assigned to "Dubious" are entries that InterPro itself considers unreliable.