Frame disruptions in human mRNA transcripts, and their relationship with splicing and protein structures

BMC Genomics

Table 4 Frame disruption placement and alternative splicing

Type of initial frame disruption	Alignment verification	Type of exon *
		Observed [constitutive : alternative]	Expected [constitutive : alternative]	Significance
Frameshift	All cases	191 : 156	258.8 : 88.2	†††
	Cases with verifying alignments	156 : 125	209.6 : 71.4	†††
Stop codon	All cases	33 : 40	54.4 : 18.6	†††
	Cases with verifying alignments	13 : 26	29.1 : 9.9	†††
Frameshift or stop codon	All cases	228 : 191	312.5 : 106.5	†††
	Cases with verifying alignments	174 : 151	242.4 : 82.7	†††
	Cases with verifying alignments (without 'probable UTR features')	114 : 95	143.8 : 65.2	†††

* Ratios are for numbers expected or observed in constitutive exons versus alternative ones. Expectations and test are performed as for Table 1.

ISSN: 1471-2164