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Table 2 List of the TGFβ1 interactome hubs.

From: Genes involved in TGFβ1-driven epithelial-mesenchymal transition of renal epithelial cells are topologically related in the human interactome map

GB accession ID

EntrezGene ID

Gene Symbol

Gene description

Log ratio

AK002171

7046

TGFBR1

transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa)

1,04

NM_001456

2316

FLNA

filamin A, alpha (actin binding protein 280)

0,77

NM_002026

2335

FN1

fibronectin 1

0,73

NM_001100

58

ACTA1

actin, alpha 1, skeletal muscle

0,62

NM_005157

25

ABL1

v-abl Abelson murine leukemia viral oncogene homolog 1

0,61

AK024230

7532

YWHAG

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

0,61

NM_000389

1026

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

0,60

NM_002859

5829

PXN

paxillin

0,58

NM_053056

595

CCND1

cyclin D1

0,55

NM_004087

1739

DLG1

discs, large homolog 1 (Drosophila)

0,54

NM_006597

3312

HSPA8

heat shock 70 kDa protein 8

0,49

NM_004346

836

CASP3

caspase 3, apoptosis-related cysteine peptidase

0,45

NM_003029

6464

SHC1

SHC (Src homology 2 domain containing) transforming protein 1

0,45

NM_005658

7185

TRAF1

TNF receptor-associated factor 1

0,44

NM_032904

5781

PTPN11

protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)

0,42

NM_005544

3667

IRS1

insulin receptor substrate 1

0,25

NM_003246

7057

THBS1

thrombospondin 1

0,20

NM_005243

2130

EWSR1

Ewing sarcoma breakpoint region 1

-0,46

NM_003177

6850

SYK

spleen tyrosine kinase

-0,48

NM_021105

5359

PLSCR1

phospholipid scramblase 1

-0,48

NM_001753

857

CAV1

caveolin 1, caveolae protein, 22 kDa

-0,50

AF130085

1499

CTNNB1

catenin (cadherin-associated protein), beta 1, 88 kDa

-0,56

NM_015400

4088

SMAD3

SMAD, mothers against DPP homolog 3 (Drosophila)

-0,62

NM_001101

60

ACTB

actin, beta

-0,63

NM_007315

6772

STAT1

signal transducer and activator of transcription 1, 91 kDa

-0,94

AK024192

11030

RBPMS

RNA binding protein with multiple splicing

-0,97

NM_000633

596

BCL2

B-cell CLL/lymphoma 2

-1,41

  1. Columns show: the GenBank accession number, the EntrezGene ID, the Gene symbol, the gene's description and the geometric mean of the log2 ratio given in Additional file 1, column N, indicating the level of gene expression.