Large-scale analysis by SAGE reveals new mechanisms of v-erbA oncogene action

BMC Genomics

Table 1 Expression of the v-ErbA target genes in T2ECs during the differentiation process or following a T3, RA or T3 and RA treatment.

Genes	Differentiation	T3	RA	T3+RA
Sca2	- -	0	+ +	+ +
LOC129881	- -	0	+	0
eIF2B2	-	0	+	+
RNF13	-	0	0	0
TGF-β1	- -	-	0	-
β-Actin	- -	0	0	0
TPT1	+	0	0	0
RPS3	0	0	0	0
NAP1L1	-	0	0	0
RPS9	+	0	0	0
RPS3a	+	0	0	0
eEF1α1	0*	0	0	0
RPL13	0	0	0	0
MGC83969	0	0	0	0
HMG17	-	0	0	0

Expression levels of v-ErbA target genes, quantified by real-time PCR, were classified into three groups as follows: (++) strong activation, (+) moderate activation, (0) no variation, (-) repression and (--) strong repression by the different treatments. The table is the synthesis of the results obtained. For actual values and conditions used – see supplementary data. We used, as the reference gene for this experiment, eEF1α1* in agreement with Damiola et al., 2004.

ISSN: 1471-2164