Table 2 Stimulators used in the mouse MmBMM and MmRAW datasets
From: Functional genomic delineation of TLR-induced transcriptional networks
Agent | Description | Engaged TLR |
|---|---|---|
LPS | Lipopolysaccharide is a component of the bacterial cell wall (gram-negative bacteria) | TLR4 |
PAM2 | Synthetic diacylated lipopeptide (mimics bacterial lipoproteins) | TLR2:6 |
PAM3 | Synthetic triacylated lipopeptide (mimics bacterial lipoproteins) | TLR1:2 |
PIC | Polyinosine-polycytidylic acid (Poly I:C) is a synthetic mimic of viral double-stranded RNA | TLR3 |
R848 | Synthetic molecule of the imidazoquinoline family (mimics a viral product) | TLR7/8 |
CpG | Mimics bacterial and viral CpG DNA motifs | TLR9 |