Table 4 Comparison of changes in gene expression in functional pathways
Process or Pathway | SHR | ACTH |
|---|---|---|
Renin-angiotensin system | ↑Ace1, ↑Atip1 |  |
MAP kinase ERK1/2 | ↑Phb, ↑Raf1 | ↓Phb |
MAP kinase p38 | ↓Dusp1, ↓Map4k2, ↓Map2k3 | ↑Dusp1 |
G-protein signalling | ↑Gnb2, ↑Rac1 ↓Rgs2, ↓Rgs5 | ↑Gnb2, ↑Rac1 ↓Rgs2, ↓Rgs5 |
cAMP | ↓Adcy3, ↓Akap12 | ↑Akap12 ↓Adcy2, ↓Adcy3 |
PKC | ↑Pkcη ↓Pkcι |  |
Nitric oxide | ↑Caveolin-1 | ↑Caveolin-1 |
Endothelins | ↑EdnrB |  |
Reactive oxygen stress | ↑Rac1 ↓Rtp801, ↓Egln3 | ↑Rac1 ↓Rtp801 |
Calcium handling | ↑Anxa3, ↑Anxa4, ↑Anxa7, ↑Casq2, ↑Efhc1, ↑S100A16 ↓Anxa8, ↓Anxa11, ↓Nucb2 | ↑Anxa4, ↑Anxa7, ↑Efhc1 |
Ion transport | ↑Atp1b1, ↑Kcnmb1 ↓Clcn3e, ↓Sat, ↓Ttyh1 | ↓Cacnb2, ↓Clcn3e, ↓Ttyh1 |
Mitochondrial activity | ↑Aco2, ↑Mrpl3, ↑Mrpl48, ↑Mrps18b, ↑Ndufs2 ↓Frda, ↓Mrpl4, ↓Pdk2, ↓Ssbp1, ↓Timm22 | ↓Ndufs3, ↓Pdk2 |
Growth promoting | ↑Minpp1, ↑P-Rex1, ↑Myof, ↑Ceacam1, ↑Ctgf, ↑Vegfr, ↑Vegfr1 ↓Aebp1, ↓Igfbp2, ↓Klf9, ↓Bmp4, ↓Igfbp5 | ↑Bmp4, ↑Ceacam1, ↑Ctgf, ↑Vegfr ↓Aebp1, ↓Igfbp2, ↓Igfbp5, ↓Klf9, ↓p311, ↓Pdgrfl |
Growth suppressing | ↓Basp1, ↓Bmp6, ↓Cst3, ↓Gas5, ↓Kank, ↓Stk11ip, ↓SerpinB5, ↓Smurf2, ↓Smoc1, ↓Tem7, ↓Tnmd | ↑Gas5, ↑Igfbp3, ↑Wisp-2 ↓Basp1, ↓Tem7, ↓Tnmd |
Insulin & glucose transport | ↑Sord, ↑Glud1, ↑Enpp1, ↑Gsk3β ↓Bpgm, ↓Pcsk1, ↓Sort1 | ↑Sord, ↑Glud1 ↓Bpgm, ↓Pcsk1, ↓Sort1, ↓Gsk3β |
Lipid metabolism | ↑Phb ↓Decr1, ↓Acsl3, ↓Mafb | ↑Acsl1, ↑Hmgcs2 ↓Lpl, ↓Phb |
Extracellular matrix | ↑Icap1, ↑Fyn ↓Col1A2, ↓Icam2, ↓Lox, ↓Loxl, ↓Sdc1, ↓Slit3 | ↑Fyn ↓Col1A1, ↓Col1A2, ↓Col3A1, ↓Col4A1, ↓Col4A2, ↓Col5A1, ↓Col8A1, ↓Col12A1, ↓Col15A1, ↓Col18A1, ↓Lox, ↓Loxl, ↓Sdc1, ↓SerpinH1, ↓Slit3 |
Smooth muscle-related genes | ↑Acta1, ↑CaMkIId, ↑Ca3, ↑Fgl2, ↑Ldha, ↑Myof1, ↑Raf1, ↑Pcmt1 ↓Aebp1, ↓Cst3, ↓Des, ↓Gas5 | ↑Acta1, ↑Ca3, ↑Cnn3, ↑Gas5, ↑Igfbp3 ↓Aebp1, ↓CaMkIId, ↓Gadd45, ↓p311 |
Endothelium-related genes | ↑Cxcl12, ↑Ecmn, ↑Gp38, ↑Hmox2, ↑Mmn1,↑Thbd ↓Recs1, ↓Tem7, ↓vWF | ↑Gp38, ↑Mmn1, ↑Thbd ↓Angpt2, ↓Tem7 |