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Table 3 Genes up-regulated in Parp-1-/- ES cells

From: Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

 

Fold changea)

   

Accession No.

H vs W

210-58 vs J1

226-47 vs J1

Symbol

Chromosome

Gene description

Cell cycle/cell proliferation/cell death

      

X58196

3.1

3.3

2.9

H19

7

H19 non-coding RNA

AI842665

3.0

3.1

2.8

Tax1bp3

11

Human T-cell leukemia virus type I binding protein 3

Cell structure/cell adhesion

      

X04017

2.3

2.3

2.3

Sparc

11

Cysteine-rich glycoprotein SPARC

M26071

2.1

2.5

1.8

F3

3

Coagulation factor III

M91236

2.1

2.1

2.1

Gjb5

4

Gap junction membrane channel protein beta 5

Immune response

      

U13705

2.3

2.1

2.4

Gpx3

11

Glutathione peroxidase 3

Metabolism

      

AW120625

2.3

1.9

2.7

Pgd

4

Phosphogluconate dehydrogenase

M64782

2.2

1.9

2.5

Folr1

7

Folate-binding protein 1 (FBP1)

X97755

2.0

2.1

2.0

Ebp

x

Phenylalkylamine Ca2+ antagonist (emopamil) binding protein

Protein biosynthesis/degradation

      

W71352

3.9

4.2

3.6

Bag2

1

Bcl2-associated athanogene 2

AI844175

3.4

3.4

3.4

Mrps11

7

Mitochondrial ribosomal protein S11

U16163

2.9

2.9

2.8

P4ha2

11

Prolyl 4-hydroxylase alpha(II)-subunit

D00622

2.5

2.0

3.0

Lrpap1

5

Low density lipoprotein receptor related protein, associated protein 1

X60676

2.3

2.4

2.2

Serpinh1

7

HSP47

AW124432

2.1

1.8

2.5

Mrpl12

11

Mitochondrial ribosomal protein L12

AI839392

2.0

2.0

2.1

Aars

8

Alanyl-tRNA syntase

Transcription/replication

      

D49473

3.4

3.0

3.7

Sox17

1

SRY-box containing gene 17

U51335

2.5

2.5

2.6

Gata6

18

GATA-binding protein 6

U79962

2.4

2.1

2.6

Tarbp2

15

TAR (HIV) RNA binding protein 2

D49473

2.1

1.9

2.3

Sox17

1

SRY-box containing gene 17

Transport

      

D14077

2.2

2.1

2.2

Clu

14

Clusterin

Others

      

M34603

2.6

2.3

3.0

Prg

10

Proteoglycan core protein

AA793009

2.3

2.0

2.7

Tex19

11

Testis expressed gene 19

Unknown

      

AI846553

3.2

3.0

3.3

1110020C13Rik

15

Hypothetical protein

AI845664

2.1

2.0

2.2

Grwd

7

Glutamate-rich WD repeat containing 1

  1. a) H, Parp-1-/- ES cells (210-58 and 226-47); W, wild-type cells (J1).