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Figure 10 | BMC Genomics

Figure 10

From: Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction

Figure 10

Proposed F3-induced cell death pathways in THP-1 cells. Based on our self-developed software for the reconstruction of gene networks in addition to literature research, we proposed plausible cell death pathways induced by F3 in THP-1 cells. F3 may induce death receptor ligands (TNF-α and TRAIL) to initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Lastly, cell shrinkage and apoptosis occur.

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BMC Genomics

ISSN: 1471-2164

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