Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice

Table 1 Enrichment of the 327 genes differentially expressed^a in Gene Ontology terms

Cluster, GO term	Fisher exact test^b
Cluster A
Defense response^c	0.043
Cluster B
...	...
Cluster C
Positive regulation of cell activation^c	0.0024
Positive regulation of lymphocyte	0.0024
activation^c
Positive regulation of cellular	0.006
physiological process^c
Regulation of phosphorylation^c	0.008
Cell death	0.013
Positive regulation of immune response	0.015
Positive regulation of cellular	0.036
biosynthesis
Cytokines and inflammatory response	0.049
Cluster D
...	...
Cluster E
Defense response	0.0000001 ^d
Immune response	0.000004^d
Response to pest/pathogen/parasite	0.0000051^d
Inflammatory response	0.0027
Response to stress	0.0028
Response to wounding	0.003
Chemotaxis	0.0054
Response to external stimulus	0.011

^a This set of genes was extracted from the full data set (n = 2012) by use of a SAM procedure and a false discovery rate of 0%.
^b Significant results with a Fischer exact test (P < 0.05).
^c GO terms that were also over-represented in the set of 177 significant CM genes.
^d Significant results with the Benjamini multi-testing correction (P < 0.05).

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